Many metabolites are maintained at steady-state concentrations that are far from equilibrium. A comparison of Kég and Q, the mass-action ratio, can determine whether a metabolic reaction is far from equilibrium. The equation for this equilibrium is, fructose 6-phosphate + ATP fructose 1,6-bisphosphate + ADP Calculate Ko for this reaction at T = 25.0 °C. AG' = -14.2 kJ/mol Calculate the mass-action ratio, Q, from the approximate physiological concentrations for rat heart tissue shown in the table. Metabolite Concentration (µM) fructose 6-phosphate 82.0 Q = fructose 1,6-bisphosphate 31.0 АТР 12,900 ADP 1,390

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Many metabolites are maintained at steady-state concentrations that are far from equilibrium. A comparison of Keg and Q, the
mass-action ratio, can determine whether a metabolic reaction is far from equilibrium.
The equation for this equilibrium is,
fructose 6-phosphate + ATP = fructose 1,6-bisphosphate + ADP
Calculate Keg for this reaction at T = 25.0 °C.
AG' = -14.2 kJ/mol
Keg =
Calculate the mass-action ratio, Q, from the approximate physiological concentrations for rat heart tissue shown in the table.
Metabolite
Concentration (µM)
fructose 6-phosphate
82.0
Q =
fructose 1,6-bisphosphate
31.0
АТР
12,900
ADP
1,390
Transcribed Image Text:Many metabolites are maintained at steady-state concentrations that are far from equilibrium. A comparison of Keg and Q, the mass-action ratio, can determine whether a metabolic reaction is far from equilibrium. The equation for this equilibrium is, fructose 6-phosphate + ATP = fructose 1,6-bisphosphate + ADP Calculate Keg for this reaction at T = 25.0 °C. AG' = -14.2 kJ/mol Keg = Calculate the mass-action ratio, Q, from the approximate physiological concentrations for rat heart tissue shown in the table. Metabolite Concentration (µM) fructose 6-phosphate 82.0 Q = fructose 1,6-bisphosphate 31.0 АТР 12,900 ADP 1,390
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