Make an electron-flow-mechanism for this synthetic scheme. This involves predicting major and by-products using electronic and structural effects. The arrow push mechanism must be shown.(from the reaction of α-ketoacids and oxaprolines to proteins that contain native serine residues ) with label

Make an electron-flow-mechanism for this synthetic scheme. This involves predicting major and by-products using electronic and structural effects. The arrow push mechanism must be shown.(from the reaction of α-ketoacids and oxaprolines to proteins that contain native serine residues ) with label

Curren'S Math For Meds: Dosages & Sol

11th Edition

ISBN:9781305143531

Author:CURREN

Publisher:CURREN

Chapter9: Parenteral Medication Labels And Dosage Calculation

Section: Chapter Questions

Problem 6.4P

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Question

5-oxaproline
(Opr)
1,2-oxazetidine
(Ozt)
10-15 mM
R1
R1
R2
ОН
R2
40 - 60 °C
oxalic acid
OH
a-ketoacid
Opr
Homo-serine
KAHA ligation
100 uM - 5 mM
R1
R1
R3
ОН
R3
20 - 25 °C
HO,
Özt
lower concentration
Serine
a-ketoacid
lower temperature
no additives
R1, R2, R3 = amino acid residues

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