Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Question
Look at the attached image. In A, from the data presented, what is the effect of treatment with tunicamycin alone? Explain your answer?
Transcribed Image Text:A
Tm
МKС-3946 (иM)
+ +
O 25 5 10 0 25 5 10
XBP1U
XBP1S D
B
1200
o-saline
1000
-мку-3946
800
600
400
200
7
14
21
28
35
42
days post-challenge
(A). Multiple myeloma (MM) cells from a human donor were either treated or not with Tm, in combination with a range of
concentrations (0-10 uM) of the compound MKC-3946. After 3 h total RNA was extracted and XBP1 RNA was amplified by RT-
PCR. The products were electrophoresed through a 3.5% agarose to separate unspliced XBP1 from spliced XBP1S.
(B). Severe combined immunodeficient (SCID) mice have severe defects in their adaptive immunity system, and make virtually no T
and B lymphocytes. Thus they will accept human xenografts without rejection. SCID mice were injected subcutaneously with 1 x107
MM cells on day 0 and treated daily with intraperitoneal saline (white circles. n = 8) or MKC-3946 (black circles, n = 8). Tumour
volume was calculated from calliper measurements and the data are shown as mean +/- SEM.
tumour volume(mm2)
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