You've discovered a new gene, G8R. Describe two experiments you could do to determine whether it is a proto-oncogene. Explain the experimental set-up as well a how you would interpret the results.
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You've discovered a new gene, G8R. Describe two experiments you could do to determine whether it is a proto-oncogene. Explain the experimental set-up as well a how you would interpret the results.
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It seems that the expert answer touches on many points, but does not address the question precisely, which two experiments could do to determine whether it is a proto-oncogene and the experiment set-up as well as how would interpret the results.
- Give a schematic diagram of how we can Treatment Down's syndrome by using gene therapy? Please answer at your own words,please..Do you agree or disagree why? Prior to this video I had not been introduced to the concept of genetically modified babies or "designer babies". However, a concept that was brought up in comparison to the designer babies was IVF babies. This concept is more familiar to me and made me think of the great possibilities designer babies could bring, but at what cost? As IVF first became popular it seemed to be well known that was was a possibility for well-off financially families. Although designer babies may have benefits such as lowering the risk to develop hereditary diseases, I don't think this concept would be widely accessible to varying income levels.A graduate student who has not taken BIOL 519 thinks they have discovered a new oncogene that could cause breast cancer. The student transfects cells with this oncogene and finds that the cells proliferate uncontrollably. The student next designs a PCR assay that will detect the presence of the oncogene in cancerous breast tissue. The student sets up the assay and analyzes the presence of the oncogene in normal and tumor issue samples (See data below). The student is disappointed to see that the potential oncogene is present at similar levels in both the normal and tumor tissue. Therefore, the student concludes that this gene is not an oncogene. Do you agree with this conclusion? Justify your answer (5-6 senetences max). Oncogene? GADPH Normal Tumor 1 Tumor 2 Tumor 3
- Proto-oncogenes can be converted to oncogenes in a number of different ways. In some cases, the proto-oncogene itself becomes amplified up to hundreds of times in a cancer cell. An example is the cyclin D1 gene, which is amplified in some cancers. In other cases, the proto-oncogene may be mutated in a limited number of specific ways, leading to alterations in the gene product’s structure. The ras gene is an example of a proto-oncogene that becomes oncogenic after suffering point mutations in specific regions of the gene. Explain why these two proto-oncogenes (cyclin D1 and ras) undergo such different alterations in order to convert them into oncogenes.A graduate student who has not taken BIOL 519 thinks they have discovered a new oncogene that could cause breast cancer. The student transfects cells with this oncogene and finds that the cells proliferate uncontrollably. The student next designs a PCR assay that will detect the presence of the oncogene in cancerous breast tissue. The student sets up the assay and analyzes the presence of the oncogene in normal and tumor issue samples (See data below). The student is disappointed to see that the potential oncogene is present at similar levels in both the normal and tumor tissue. Therefore, the student concludes that this gene is not an oncogene. Do you agree with this conclusion? Justify your answer (5-6 senetences max).Pinpointing a disease gene requires a combination of approaches. Mutations in the XIAP gene are known to cause a serious condition called X-linked lymphoproliferative disease (XLPD). In the case of XLPD, in which the blood contains too many lymphocytes (white blood cells of the immune system), crowding out the oxygen-carrying red blood cells and damaging the liver. When compairing the XIAP amino acid sequence of one affected patient to other human and animal standard RefSeq, the patient has an amino acid substitution at position 203, from cystenine (C) to tyrosing (Y). This evolutionary conservation suggests Group of answer choices that the standard RefSeq does not provide enough information to determine a possible cause of XIAP function. mutations in the XIAP gene and XLPD are not associated. that the mutation in the affected patient has no impact on XIAP function. that the mutation in the affected patient might alter XIAP function.
- Why do cells have proto-oncogenes? What is their function? Use specific examples in your explanation.A couple with a child affected with DBA undergoes in vitro fertilization (IVF) and genetic testing of the resulting embryos to ensure that the embryos will not have DBA. However, they also want the embryos screened to ensure that the one implanted can serve as a suitable donor for their existing child. Their plan is to have stem cells from the umbilical cord of the new baby transplanted to their existing child with DBA, thereby curing the condition. What are the ethical pros and cons of this situation?Give a schematic diagram of how we can Treatment Sickle Cell Anemia by using gene therapy? Please answer at your own words,please..
- You’ve made your construct and placed it into E. coli! Congratulations, you have made a transgenic organism. Your investors will want to know about quality control. How will you check that the correct piece of DNA is in your vector? How will you check to make sure the gene is transcribed? How will you check to make sure that the GasP protein is made in E. coli? Your investors are concerned that the GasP protein might not be sufficiently produced under normal laboratory conditions. They suggest controlling the transcription of the gasP gene using a chemical that will “trigger” its transcription. What type of promoter could be used? What chemical will you use to control transcription? How does this method of control work?Give a schematic diagram of how we can Treatment Down Syndrome by using gene therapy? Please answer at your own words,please..A 60 years old man comes to your clinic presenting with stomach pain, sore muscles, fever, and dark urine. He has also poor appetite and nausea. Laboratory findings are the elevation of liver enzymes. Finally PCR results declared that he is suffering from HCV. There exist so many biological, genetic and environmental factors that he might be suffered from Hepatocellular Carcinoma (HCC). Research findings indicate that this transformation may be due to Single Nucleotide Polymorphism (SNPs) of any of the gene (like SNP in TGF-beta). By having the knowledge of molecular techniques writes the name and full form of that technique that can be used for the determination of SNP