In the hedgehog signaling pathway, which of the following enters the nucleus to activate transcription upon ligand bínding to the receptor? A Smoothened B Full-length (intact) Gli Cleaved Gli Patched E) Shh
In the hedgehog signaling pathway, which of the following enters the nucleus to activate transcription upon ligand bínding to the receptor? A Smoothened B Full-length (intact) Gli Cleaved Gli Patched E) Shh
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Question
Transcribed Image Text:**Question:**
In the hedgehog signaling pathway, which of the following enters the nucleus to activate transcription upon ligand binding to the receptor?
**Options:**
A) Smoothened
B) Full-length (intact) Gli
C) Cleaved Gli
D) Patched
E) Shh
**Explanation:**
This question pertains to the mechanism of the hedgehog signaling pathway, which is crucial for various developmental processes. It involves the activation of specific transcription factors that enter the nucleus to regulate gene expression. The correct answer can be deduced by understanding the roles of the components listed in the options.
Transcribed Image Text:**Question**: Which of the following processes DOES NOT involve EMT?
**Options**:
- **A) Cancer metastasis.**
- **B) Formation of the neural crest.**
- **C) Cleavage in the morula.**
- **D) Formation of vertebrae precursor cells.**
- **E) Wound healing.**
*Note*: EMT stands for Epithelial-Mesenchymal Transition, a process whereby epithelial cells transform into mesenchymal stem cells, which is important in various biological processes.
Expert Solution
Step 1
Cell signaling pathways are found in multicellular organisms and they fall under the mechanisms involved in developmental biology. Hedgehog signaling leads to activation of cell division or Mitogenesis. This pathway is activated by the Hedgehog Protein (Hh).
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