(ii) (iii) Shown below is a redox activated prodrug 1 for gene-directed enzyme prodrug therapy (GDEPT) where E. coli nitro reductase gene has been introduced to the cancer cells. Show both the mechanism of conversion of the prodrug and the products that will be produced when the prodrug is acted on by E. coli nitro-reductase. [15 marks] NO₂ NO₂ OH Compound 2 below was also prepared as a potential redox activated prodrug for GDEPT. However, the biological activity of 2 was very poor compared to 1. Explain the difference in the observed biological activity between 1 and 2. [10 marks] OH NH 2 NH

(ii) (iii) Shown below is a redox activated prodrug 1 for gene-directed enzyme prodrug therapy (GDEPT) where E. coli nitro reductase gene has been introduced to the cancer cells. Show both the mechanism of conversion of the prodrug and the products that will be produced when the prodrug is acted on by E. coli nitro-reductase. [15 marks] NO₂ NO₂ OH Compound 2 below was also prepared as a potential redox activated prodrug for GDEPT. However, the biological activity of 2 was very poor compared to 1. Explain the difference in the observed biological activity between 1 and 2. [10 marks] OH NH 2 NH

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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