4. Following is the mechanism proposed for the inactivation of monoamine oxidaseby N-cyclopropyl-a-methyl benzylamine. The reaction uses flavin (Fl) coenzyme.In the first step, the flavin is an oxidant accepting one electron from the aminesubstrate making it a (cation) radical. Propose the step-by-step mechanisms forthe last two steps of the reactions circled.при приCH3FI FISUPh NH3.88HOnámNaBH4PhCH3HSmhmPhمسکن به ۳۰ بهH₂OH₂FI SCH3Ph NH₂CH3PhHCH3HприFIH SwhSwhu

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Answered: 4. Following is the mechanism proposed…

4. Following is the mechanism proposed for the inactivation of monoamine oxidase by N-cyclopropyl-a-methyl benzylamine. The reaction uses flavin (Fl) coenzyme.

Organic Chemistry

8th Edition

ISBN:9781305580350

Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Chapter18: Functional Derivatives Of Carboxylic Acids

Section: Chapter Questions

Problem 18.60P

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Question

4. Following is the mechanism proposed for the inactivation of monoamine oxidase
by N-cyclopropyl-a-methyl benzylamine. The reaction uses flavin (Fl) coenzyme.
In the first step, the flavin is an oxidant accepting one electron from the amine
substrate making it a (cation) radical. Propose the step-by-step mechanisms for
the last two steps of the reactions circled.
при при
CH3
FI FI
SU
Ph N
H
3.88
HO
nám
NaBH4
Ph
CH3
H
S
mhm
Ph
مسکن به ۳۰ به
H₂O
H₂
FI S
CH3
Ph NH₂
CH3
Ph
H
CH3
H
при
FIH S
wh
S
whu

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