4. Following is the mechanism proposed for the inactivation of monoamine oxidase by N-cyclopropyl-a-methyl benzylamine. The reaction uses flavin (Fl) coenzyme.
4. Following is the mechanism proposed for the inactivation of monoamine oxidase by N-cyclopropyl-a-methyl benzylamine. The reaction uses flavin (Fl) coenzyme.
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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Transcribed Image Text:4. Following is the mechanism proposed for the inactivation of monoamine oxidase
by N-cyclopropyl-a-methyl benzylamine. The reaction uses flavin (Fl) coenzyme.
In the first step, the flavin is an oxidant accepting one electron from the amine
substrate making it a (cation) radical. Propose the step-by-step mechanisms for
the last two steps of the reactions circled.
при при
CH3
FI FI
SU
Ph N
H
3.88
HO
nám
NaBH4
Ph
CH3
H
S
mhm
Ph
مسکن به ۳۰ به
H₂O
H₂
FI S
CH3
Ph NH₂
CH3
Ph
H
CH3
H
при
FIH S
wh
S
whu
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