II III IV PART A. What is the likely mode of inheritance of the condition shown in this pedigree and explain how you know? PART B. Assume that individuals that are not direct descendants of I-1 and I-2 are unaffected. Fill in the genotypes for each individual (list out: I-1, I-2, I1-1, Il-2, II-3, I1-4, I1-5, Il-6, Il-7, II-8, III-1, Il-2, III-3,1II-4,1II-5, III-6,1II-7, IV-1, IV-2, IV-3, IV-4, IV-5, IV-6). Use or ? for unknown alleles PART C. What is the probability that individual IV-2 carries an allele for the condition? PART D. What is the probability that individual IV-5 carries an allele for the condition?

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Chapter14: Allergy: An Overview
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II O
5 6
III O
IV
4
PART A. What is the likely mode of inheritance of the condition shown in this
pedigree and explain how you know?
PART B. Assume that individuals that are not direct descendants of l-1 and I-2 are unaffected. Fill in the genotypes for each individual (list out: I-1, I-2, Il-1, Il-2, II-3, Il-4, Il-5, Il-6,
IlI-7, Il-8, III-1, III-2, III-3,1II-4,1II-5, III-6,1II-7, IV-1, IV-2, IV-3, IV-4, IV-5, IV-6). Use_or ? for unknown alleles
PART C. What is the probability that individual IV-2 carries an allele for the condition?
PART D. What is the probability that individual IV-5 carries an allele for the condition?
PART E. If couple III-6 and III-7 have another child, what is the probability the child will be affected?
PART F. If couple couple III-4 and III-5 have another child, what is the probability the child will be affected?
PART G. All of the parents described (II-4, 5..6 and 7) do not have the condition. Explain why the probabilities that they have an affected child differ.
Transcribed Image Text:II O 5 6 III O IV 4 PART A. What is the likely mode of inheritance of the condition shown in this pedigree and explain how you know? PART B. Assume that individuals that are not direct descendants of l-1 and I-2 are unaffected. Fill in the genotypes for each individual (list out: I-1, I-2, Il-1, Il-2, II-3, Il-4, Il-5, Il-6, IlI-7, Il-8, III-1, III-2, III-3,1II-4,1II-5, III-6,1II-7, IV-1, IV-2, IV-3, IV-4, IV-5, IV-6). Use_or ? for unknown alleles PART C. What is the probability that individual IV-2 carries an allele for the condition? PART D. What is the probability that individual IV-5 carries an allele for the condition? PART E. If couple III-6 and III-7 have another child, what is the probability the child will be affected? PART F. If couple couple III-4 and III-5 have another child, what is the probability the child will be affected? PART G. All of the parents described (II-4, 5..6 and 7) do not have the condition. Explain why the probabilities that they have an affected child differ.
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