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i) After the first stimulus, how does the excitatory postsynaptic potential (EPSP) you record from the postsynaptic neuron differ from the EPSP recorded from a wild-type animal? Does it increase, decrease, stay comparatively the same, or fail to be generated at all? ii) After five stimulations of the presynaptic cell in quick succession, how does the EPSP you record from the mutant animal differ from that in the same experiment on a wild-type animal?

i) After the first stimulus, how does the excitatory postsynaptic potential (EPSP) you record from the postsynaptic neuron differ from the EPSP recorded from a wild-type animal? Does it increase, decrease, stay comparatively the same, or fail to be generated at all? ii) After five stimulations of the presynaptic cell in quick succession, how does the EPSP you record from the mutant animal differ from that in the same experiment on a wild-type animal?

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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### Exercise: Analyzing Synaptic Responses in Mutant and Wild-Type Animals **Objective:** To study the differences in excitatory postsynaptic potential (EPSP) responses between mutant animals and wild-type animals under specific experimental conditions. **Procedure:** You stimulate a presynaptic cell and record from the postsynaptic neuron of each pair. For each mutation described below, answer the following questions: 1. **Initial Stimulus Response:** - After the first stimulus, how does the excitatory postsynaptic potential (EPSP) recorded from the postsynaptic neuron in the mutant animal differ from the EPSP recorded from a wild-type animal? - Does it increase, decrease, stay comparatively the same, or fail to be generated at all? 2. **Repeated Stimulation Response:** - After five stimulations of the presynaptic cell in quick succession, how does the EPSP recorded from the mutant animal differ from the EPSP recorded under the same conditions in a wild-type animal? **Instructions:** Explain your reasoning for each case, considering potential impacts of the mutations on synaptic transmission processes. --- **Detailed Analysis:** **Part i) Initial Stimulus Response:** - Compare the magnitude and occurrence of the EPSP in the postsynaptic neuron of the mutant animal to that of a wild-type animal after a single stimulus. **Part ii) Repeated Stimulation Response:** - Assess the pattern and changes in the EPSP after five rapid stimulations, comparing the responses in the mutant animal to those in the wild-type animal. **Considerations:** - Synaptic vesicle release probability - Receptor density and functionality on the postsynaptic membrane - Short-term synaptic plasticity mechanisms such as facilitation or depression **Note:** Include detailed explanations and possible mechanisms leading to observed differences for each mutation, supported by underlying neuroscientific principles. --- *This exercise helps in understanding the fundamental concepts of synaptic transmission, plasticity, and the impact of genetic mutations on neural signaling.*
Transcribed Image Text:### Exercise: Analyzing Synaptic Responses in Mutant and Wild-Type Animals **Objective:** To study the differences in excitatory postsynaptic potential (EPSP) responses between mutant animals and wild-type animals under specific experimental conditions. **Procedure:** You stimulate a presynaptic cell and record from the postsynaptic neuron of each pair. For each mutation described below, answer the following questions: 1. **Initial Stimulus Response:** - After the first stimulus, how does the excitatory postsynaptic potential (EPSP) recorded from the postsynaptic neuron in the mutant animal differ from the EPSP recorded from a wild-type animal? - Does it increase, decrease, stay comparatively the same, or fail to be generated at all? 2. **Repeated Stimulation Response:** - After five stimulations of the presynaptic cell in quick succession, how does the EPSP recorded from the mutant animal differ from the EPSP recorded under the same conditions in a wild-type animal? **Instructions:** Explain your reasoning for each case, considering potential impacts of the mutations on synaptic transmission processes. --- **Detailed Analysis:** **Part i) Initial Stimulus Response:** - Compare the magnitude and occurrence of the EPSP in the postsynaptic neuron of the mutant animal to that of a wild-type animal after a single stimulus. **Part ii) Repeated Stimulation Response:** - Assess the pattern and changes in the EPSP after five rapid stimulations, comparing the responses in the mutant animal to those in the wild-type animal. **Considerations:** - Synaptic vesicle release probability - Receptor density and functionality on the postsynaptic membrane - Short-term synaptic plasticity mechanisms such as facilitation or depression **Note:** Include detailed explanations and possible mechanisms leading to observed differences for each mutation, supported by underlying neuroscientific principles. --- *This exercise helps in understanding the fundamental concepts of synaptic transmission, plasticity, and the impact of genetic mutations on neural signaling.*
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