Hydrolysis of a decapeptide yields the following amino acids.ala, asp, arg, his, leu, lyS, met, tyrThe following fragments produced upon subjecting the decapeptide to various enzymatic and chemicahydrolysisSanger's method: DNP-arg and nonapeptideCyanogen bromide. met, leu-asp-his, and hexapeptideTrypsin: arg, ala-lys, and heptapeptideChymotrypsin: tyr, arg-ala-lys-tyr, and pentapeptideCarboxypeptidase: his and nonapeptideDetermine the amino acid sequence of the decapeptide:[ Select 1

sanger's method decapeptide treated with sanger's reagent(1 fluoro 2.4 dinitrobenzene) yeilds…

Answered: Hydrolysis of a decapeptide yields the…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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You are presented with Cytidine 5' triphosphate and Thymidine 5' triphosphate. Draw and upload to Efundi these phosphorylated structures as they would be connected in a polinucleotide in the order CpT / Show the individual phosphorylated structures first then show how they combine to form the polynuleotide. Show at any one of these structures where the glycosidic bond occurs
The majority of amino acid residues found in the portion of a beta-barrel in contact with the transported solute are O hydrophobic O cyclic O hydrophilic O aromatic Previous Nort
a. Suppose that you have the peptide Ala-Gly-Tyr-His-Leu and you treat it with FDNB and then 6M HCl. Draw the structures of all the products that you will have in solution (assume all reactions to go to completion).
A sample of an unknown peptide was divided into two aliquots. One aliquot was treated with trypsin and the other was treated with cyanogen bromide. Given the following sequences (N-terminal to C-terminal) of the resulting fragments, deduce the sequence of the original peptide. Trypsin treatment Asn—Tyr—Asp—Met—Phe—Ala—Arg Asp—Trp—Asn—Arg Gln—Met—Tyr—Cys—Pro—Ile—Arg Gln—Cys Cyanogen bromide treatment Tyr—Cys—Pro—Ile—Arg—Asn—Tyr—Asp—Met Asp—Trp—Asn—Arg—Gln—Met Phe—Ala—Arg—Gln—Cys
Small molecules are used as inhibitors of protein action - as drugs. They most often do this by blocking the active site within the protein. Potential drugs can be screened computationally to determine if they are strongly bound to the protein. Figure 1 shows a possible conformation of a candidate drug molecule, 4-bromo-2- carboxymethylamide-pyrrole (abbreviation: BCMAP) at the active site of a protein (abbreviation: PR). Figure 2 shows the full protein structure whilst figure 3 shows a known inhibitor of the protein at the site, overlayed with another calculated conformer of BCMAP. (a) Explain what types of interactions, both intermolecular and intramolecular, that a molecular mechanics forcefield must be able to describe in order to be able to accurately determine the geometry of BCMAP in the protein. Identify which interactions will be the most important to describe accurately. Figure 1.4-bromo-2-carboxymethylamide-pyrrole (BCMAP) (C, N, O, and Br atoms in yellow, blue, red, and…
using cysteine, serine, and aspartic acid create a tripeptide by performing 2 dehydration synthesis reactions
what does the Hexa protein domain depict? (in relation with tay sachs disease)
Protease enzymes cleave proteins by hydrolyzing peptide bonds. The strategy for each type of metalloprotease begins with generating a nucleophile that attacks the peptide bond that attacks the peptide carbonyl group. Macmillan Learning On the basis of the information provided in the figure, show the next step in the mechanism for peptide-bond cleavage by a cysteine protease. H Cysteine proteases R₂ HN R₁ Draw curved arrows on the pre-drawn structures to show the cysteine protease mechanism. If you need to reset the structures, click More followed by Reset Drawing. Select Draw Templates Groups More N R2 H \.. C O S R1 Erase N
Label all structures as appropriate. Draw and label all appropriate molecules to complet the pictures.
A researcher has synthesized two peptides and needs to confirm whether the peptides were synthesized with the correct sequence using mass spectrometry. What is the sequence of the b4 and y7 ions for peptide GAMECHANGER? The peptide SLISRAEFLAGVRVGV is digested with trypsin. Then the products of the digestion are subjected to ESI TOF-MS in positive ion mode with the peptides in a pH 2 solution. What peptide fragments will result and what are their m/z?
To make Cytidine 5'-triphosphate we must ALVWAYS first make which nucleotide? Adenylate Thymidylate Inosinate O Xanthylate O Uridylate Guanylate

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