How do you think an inhibitor will interact with the active site of cyclooxygenase? Will there be any pi stacking? Hydrogen bonds? Ion-dipole interactions? Salt bridges?
How do you think an inhibitor will interact with the active site of cyclooxygenase? Will there be any pi stacking? Hydrogen bonds? Ion-dipole interactions? Salt bridges? How large is the inhibitor? Will it fit perfectly?
An enzyme inhibitor stops or inhibits the process, either by preventing the substrate from binding by binding itself to the enzyme's active site or by binding to the another site on the enzyme such that the enzyme's catalysis of the reaction is blocked. These inhibitors can bind reversibly or irreversibly.
there are three types of inhibition reactions:
a) Non-Competitive
b) Uncompetitive
c) Competitive
Cyclooxygenase is found in 2 forms COX-1, COX-2. Both COX-1 and COX-2 produce the prostaglandins that contribute to pain , inflammation and fever. NSAIDs ( Nonsteroidal anti-inflammatory drugs) inhibit both forms of cyclooxygenase.
their mechanism of action is based on the blockage of the cyclooxygenase enzymes (COXs) by sterically hindering the entrance of the physiological binder arachidonic acid.
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