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Determine whether each of the inhibitors (or inhibitor characteristics) are involved in reversible inhibition or irreversible inhibition. a) inhibitor structure often resembles the substrate structure reversible inhibition b) inhibitor forms a new and permanent covalent bond to the enzyme's active site irreversible inhibition c) sulfanilamide reversible inhibition d) aspirin irreversible inhibition e) inhibitor binds weakly and noncovalently to an enzyme's active site and decreases its activity reversible inhibition f) penicillin V irreversible inhibition g) inhibitor binds weakly and noncovalently to the enzyme at a region other than the active site reversible inhibition h) inhibitors repeatedly attach to and detach from enzyme reversible inhibition i) inhibitor is used in a pathway that is regulated by feedback inhibition reversible inhibition

Determine whether each of the inhibitors (or inhibitor characteristics) are involved in reversible inhibition or irreversible inhibition. a) inhibitor structure often resembles the substrate structure reversible inhibition b) inhibitor forms a new and permanent covalent bond to the enzyme's active site irreversible inhibition c) sulfanilamide reversible inhibition d) aspirin irreversible inhibition e) inhibitor binds weakly and noncovalently to an enzyme's active site and decreases its activity reversible inhibition f) penicillin V irreversible inhibition g) inhibitor binds weakly and noncovalently to the enzyme at a region other than the active site reversible inhibition h) inhibitors repeatedly attach to and detach from enzyme reversible inhibition i) inhibitor is used in a pathway that is regulated by feedback inhibition reversible inhibition

Chemistry
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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O Determine whether each of the inhibitors (or inhibitor characteristics) are involved in reversible inhibition or irreversible inhibition. a) inhibitor structure often resembles the substrate structure reversible inhibition b) inhibitor forms a new and permanent covalent bond to the enzyme's active site irreversible inhibition c) sulfanilamide reversible inhibition d) aspirin irreversible inhibition e) inhibitor binds weakly and noncovalently to an enzyme's active site and decreases its activity reversible inhibition f) penicillin V irreversible inhibition g) inhibitor binds weakly and noncovalently to the enzyme at a region other than the active site reversible inhibition h) inhibitors repeatedly attach to and detach from enzyme reversible inhibition i) inhibitor is used in a pathway that is regulated by feedback inhibition reversible inhibition EXPLANATION: Irreversible inhibition occurs when an inhibitor reacts with an enzyme, forming a new and permanent covalent bond to the enzyme. In almost all cases of irreversible inhibition, the new bond is made to the enzyme's active site, which results in complete and permanent loss of the enzyme's activity. Reversible inhibition occurs when an inhibitor is weakly bound to an enzyme and decreases its activity. Like the substrates, reversible inhibitors are specific for particular enzymes. Reversible inhibitors do not form covalent bonds to the enzyme, therefore they repeatedly attach to and detach from enzymes.
Transcribed Image Text:O Determine whether each of the inhibitors (or inhibitor characteristics) are involved in reversible inhibition or irreversible inhibition. a) inhibitor structure often resembles the substrate structure reversible inhibition b) inhibitor forms a new and permanent covalent bond to the enzyme's active site irreversible inhibition c) sulfanilamide reversible inhibition d) aspirin irreversible inhibition e) inhibitor binds weakly and noncovalently to an enzyme's active site and decreases its activity reversible inhibition f) penicillin V irreversible inhibition g) inhibitor binds weakly and noncovalently to the enzyme at a region other than the active site reversible inhibition h) inhibitors repeatedly attach to and detach from enzyme reversible inhibition i) inhibitor is used in a pathway that is regulated by feedback inhibition reversible inhibition EXPLANATION: Irreversible inhibition occurs when an inhibitor reacts with an enzyme, forming a new and permanent covalent bond to the enzyme. In almost all cases of irreversible inhibition, the new bond is made to the enzyme's active site, which results in complete and permanent loss of the enzyme's activity. Reversible inhibition occurs when an inhibitor is weakly bound to an enzyme and decreases its activity. Like the substrates, reversible inhibitors are specific for particular enzymes. Reversible inhibitors do not form covalent bonds to the enzyme, therefore they repeatedly attach to and detach from enzymes.
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