ve Site Models27) In the active site, there are two models of substrate binding. What is described in the lock-and-key model?28) What is does the 'induced-fit' model account for?Temperature Effect29) Why are most enzyme inactive at higher temperature (greater than 37-degrees Celsius)?30) Does this happen to all enzymes in all species?31) There are several modes for enzyme regulation. What's the difference between competitiveand non-competitive inhibition? (It may be helpful to diagram this.)Enzyme Co-factors32) NAD+ and FAD are essential cofactors for biological redox reactions. When they gainelectrons (and hydrogens) are they oxidized or reduced?33) What are the formulas for the reduced forms of the coenzymes?CHM60 Lecture Worksheet: Amino Acids and Proteins5

27.Each type of enzyme has a unique structure that enables a specific reaction. This means that for…

Answered: ve Site Models 27) In the active site,…

ve Site Models 27) In the active site, there are two models of substrate binding. What is described in the lock- and-key model? 28) What is does the 'induced-fit' model account for?

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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Question

ve Site Models
27) In the active site, there are two models of substrate binding. What is described in the lock-
and-key model?
28) What is does the 'induced-fit' model account for?
Temperature Effect
29) Why are most enzyme inactive at higher temperature (greater than 37-degrees Celsius)?
30) Does this happen to all enzymes in all species?
31) There are several modes for enzyme regulation. What's the difference between competitive
and non-competitive inhibition? (It may be helpful to diagram this.)
Enzyme Co-factors
32) NAD+ and FAD are essential cofactors for biological redox reactions. When they gain
electrons (and hydrogens) are they oxidized or reduced?
33) What are the formulas for the reduced forms of the coenzymes?
CHM60 Lecture Worksheet: Amino Acids and Proteins
5

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What conclusion can be drawn concerning an inhibitor if Vmax is the same in the presence and absence of the inhibitor? a. KM is smaller in the presence of the inhibitor. Ob. The inhibitor binds to the same active site as the substrate. Oc. The inhibitor binds to the substrate. Od. The inhibitor reacts with a critical residue of the enzyme. Je. The inhibitor can be overcome with sufficiently high concentrations of the substrate.
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The lock and key model and the induced fit model are two models of enzyme action explaining both the specificity and the catalytic activity of enzymes. Indicate whether each statement is part of the lock and key model, the induced fit model, or is common to both models. Lock and key model Induced fit model Common to both models Answer Bank The substrate binds to the enzyme at the active site, forming an enzyme-substrate complex. The substrate binds to the enzyme through noncovalent interactions. The enzyme conformation changes when it binds the substrate so that the active site fits the substrate. The enzyme active site has a rigid structure complementary to that of the substrate.
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