Here's a new idea for treating advanced melanoma, the most serious kind of skin cancer: genetically engineer white blood cells to better recognize and destroy cancer cells, then infuse these cells into patients. The subjects in a small initial study were 11 patients whose melanoma had not responded to existing treatments One outcome of this experiment is measured by a test for the presence of cells that trigger an immune response in the body and so may help fight cancer. Here are data for the 11 subjects: counts of active cells per 100,000 cells before and after infusion of the modified cells. The difference (after minus before) is the response variable. Before 17 1 4 4 22 4 1 After 41 11 2 218 22 700 17 532 37 96 108 Difference 24 10 217 18 699 13 510 33 89 107 (a) Explain why this is a matched pairs design. There were an even number of subjects. All of the subjects were related. O Half of the subjects took a placebo. O Each subject was measured before and after treatment. The subjects were paired off with each other. (b) Examine the data. The stemplot of differences shows a sharp right skew, and one or two high outliers. Is it reasonable to use the t procedures? O Yes, the t procedure should be used. No, the t procedure should not be used. (c) Regardless of your conclusion in part (b), using the t procedures, do the data give convincing evidence that the count of active cells is higher after treatment? PLAN: Take µ to be the mean difference (after minus before) in active cells per 100,000 cells. State the null and alternative hypotheses. о Но: и %3D 0 Hа: и > 0 о Но: и 3 0 На: и <0 О Но: и %3D 0 На: и + 0 HoiH # 0 Hạ: µ > 0 SOLVE: Calculate the test statistic. (Round your answer to three decimal places.)
Here's a new idea for treating advanced melanoma, the most serious kind of skin cancer: genetically engineer white blood cells to better recognize and destroy cancer cells, then infuse these cells into patients. The subjects in a small initial study were 11 patients whose melanoma had not responded to existing treatments One outcome of this experiment is measured by a test for the presence of cells that trigger an immune response in the body and so may help fight cancer. Here are data for the 11 subjects: counts of active cells per 100,000 cells before and after infusion of the modified cells. The difference (after minus before) is the response variable. Before 17 1 4 4 22 4 1 After 41 11 2 218 22 700 17 532 37 96 108 Difference 24 10 217 18 699 13 510 33 89 107 (a) Explain why this is a matched pairs design. There were an even number of subjects. All of the subjects were related. O Half of the subjects took a placebo. O Each subject was measured before and after treatment. The subjects were paired off with each other. (b) Examine the data. The stemplot of differences shows a sharp right skew, and one or two high outliers. Is it reasonable to use the t procedures? O Yes, the t procedure should be used. No, the t procedure should not be used. (c) Regardless of your conclusion in part (b), using the t procedures, do the data give convincing evidence that the count of active cells is higher after treatment? PLAN: Take µ to be the mean difference (after minus before) in active cells per 100,000 cells. State the null and alternative hypotheses. о Но: и %3D 0 Hа: и > 0 о Но: и 3 0 На: и <0 О Но: и %3D 0 На: и + 0 HoiH # 0 Hạ: µ > 0 SOLVE: Calculate the test statistic. (Round your answer to three decimal places.)
MATLAB: An Introduction with Applications
6th Edition
ISBN:9781119256830
Author:Amos Gilat
Publisher:Amos Gilat
Chapter1: Starting With Matlab
Section: Chapter Questions
Problem 1P
Related questions
Question
![Here's a new idea for treating advanced melanoma, the most serious kind of skin cancer: genetically engineer white blood cells to better recognize and destroy
cancer cells, then infuse these cells into patients. The subjects in a small initial study were 11 patients whose melanoma had not responded to existing treatments
One outcome of this experiment is measured by a test for the presence of cells that trigger an immune response in the body and so may help fight cancer. Here
are data for the 11 subjects: counts of active cells per 100,000 cells before and after infusion of the modified cells. The difference (after minus before) is the
response variable.
Before
17
1
4
4
22
4
1
After
41
11
2
218
22
700
17
532
37
96
108
Difference
24
10
217
18
699
13
510
33
89
107
(a) Explain why this is a matched pairs design.
There were an even number of subjects.
All of the subjects were related.
O Half of the subjects took a placebo.
O Each subject was measured before and after treatment.
The subjects were paired off with each other.
(b) Examine the data. The stemplot of differences shows a sharp right skew, and one or two high outliers. Is it reasonable to use the t procedures?
O Yes, the t procedure should be used.
No, the t procedure should not be used.
(c) Regardless of your conclusion in part (b), using the t procedures, do the data give convincing evidence that the count of active cells is higher after
treatment?
PLAN: Take µ to be the mean difference (after minus before) in active cells per 100,000 cells. State the null and alternative hypotheses.
о Но: и %3D 0
Hа: и > 0
о Но: и 3 0
На: и <0
О Но: и %3D 0
На: и + 0
HoiH # 0
Hạ: µ > 0
SOLVE: Calculate the test statistic. (Round your answer to three decimal places.)](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2Fdc86355f-6fb6-4990-8ff4-5b4da7e31b62%2F89fbe004-b070-4033-a21b-36a995d21e9e%2Fwxwee8a.png&w=3840&q=75)
Transcribed Image Text:Here's a new idea for treating advanced melanoma, the most serious kind of skin cancer: genetically engineer white blood cells to better recognize and destroy
cancer cells, then infuse these cells into patients. The subjects in a small initial study were 11 patients whose melanoma had not responded to existing treatments
One outcome of this experiment is measured by a test for the presence of cells that trigger an immune response in the body and so may help fight cancer. Here
are data for the 11 subjects: counts of active cells per 100,000 cells before and after infusion of the modified cells. The difference (after minus before) is the
response variable.
Before
17
1
4
4
22
4
1
After
41
11
2
218
22
700
17
532
37
96
108
Difference
24
10
217
18
699
13
510
33
89
107
(a) Explain why this is a matched pairs design.
There were an even number of subjects.
All of the subjects were related.
O Half of the subjects took a placebo.
O Each subject was measured before and after treatment.
The subjects were paired off with each other.
(b) Examine the data. The stemplot of differences shows a sharp right skew, and one or two high outliers. Is it reasonable to use the t procedures?
O Yes, the t procedure should be used.
No, the t procedure should not be used.
(c) Regardless of your conclusion in part (b), using the t procedures, do the data give convincing evidence that the count of active cells is higher after
treatment?
PLAN: Take µ to be the mean difference (after minus before) in active cells per 100,000 cells. State the null and alternative hypotheses.
о Но: и %3D 0
Hа: и > 0
о Но: и 3 0
На: и <0
О Но: и %3D 0
На: и + 0
HoiH # 0
Hạ: µ > 0
SOLVE: Calculate the test statistic. (Round your answer to three decimal places.)
Expert Solution
![](/static/compass_v2/shared-icons/check-mark.png)
This question has been solved!
Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.
This is a popular solution!
Trending now
This is a popular solution!
Step by step
Solved in 2 steps with 2 images
![Blurred answer](/static/compass_v2/solution-images/blurred-answer.jpg)
Recommended textbooks for you
![MATLAB: An Introduction with Applications](https://www.bartleby.com/isbn_cover_images/9781119256830/9781119256830_smallCoverImage.gif)
MATLAB: An Introduction with Applications
Statistics
ISBN:
9781119256830
Author:
Amos Gilat
Publisher:
John Wiley & Sons Inc
![Probability and Statistics for Engineering and th…](https://www.bartleby.com/isbn_cover_images/9781305251809/9781305251809_smallCoverImage.gif)
Probability and Statistics for Engineering and th…
Statistics
ISBN:
9781305251809
Author:
Jay L. Devore
Publisher:
Cengage Learning
![Statistics for The Behavioral Sciences (MindTap C…](https://www.bartleby.com/isbn_cover_images/9781305504912/9781305504912_smallCoverImage.gif)
Statistics for The Behavioral Sciences (MindTap C…
Statistics
ISBN:
9781305504912
Author:
Frederick J Gravetter, Larry B. Wallnau
Publisher:
Cengage Learning
![MATLAB: An Introduction with Applications](https://www.bartleby.com/isbn_cover_images/9781119256830/9781119256830_smallCoverImage.gif)
MATLAB: An Introduction with Applications
Statistics
ISBN:
9781119256830
Author:
Amos Gilat
Publisher:
John Wiley & Sons Inc
![Probability and Statistics for Engineering and th…](https://www.bartleby.com/isbn_cover_images/9781305251809/9781305251809_smallCoverImage.gif)
Probability and Statistics for Engineering and th…
Statistics
ISBN:
9781305251809
Author:
Jay L. Devore
Publisher:
Cengage Learning
![Statistics for The Behavioral Sciences (MindTap C…](https://www.bartleby.com/isbn_cover_images/9781305504912/9781305504912_smallCoverImage.gif)
Statistics for The Behavioral Sciences (MindTap C…
Statistics
ISBN:
9781305504912
Author:
Frederick J Gravetter, Larry B. Wallnau
Publisher:
Cengage Learning
![Elementary Statistics: Picturing the World (7th E…](https://www.bartleby.com/isbn_cover_images/9780134683416/9780134683416_smallCoverImage.gif)
Elementary Statistics: Picturing the World (7th E…
Statistics
ISBN:
9780134683416
Author:
Ron Larson, Betsy Farber
Publisher:
PEARSON
![The Basic Practice of Statistics](https://www.bartleby.com/isbn_cover_images/9781319042578/9781319042578_smallCoverImage.gif)
The Basic Practice of Statistics
Statistics
ISBN:
9781319042578
Author:
David S. Moore, William I. Notz, Michael A. Fligner
Publisher:
W. H. Freeman
![Introduction to the Practice of Statistics](https://www.bartleby.com/isbn_cover_images/9781319013387/9781319013387_smallCoverImage.gif)
Introduction to the Practice of Statistics
Statistics
ISBN:
9781319013387
Author:
David S. Moore, George P. McCabe, Bruce A. Craig
Publisher:
W. H. Freeman