he following questions apply to this information:A man licks a newt after being dared to do so by his boyfriend. Almost immediately, the man noticed that his lips and tongue felt numb. Within a few minutes, the man began to show a lack of coordination and skeletal muscle control. Within several more minutes, the man experienced difficulty breathing and symptoms of cardiac arrest. Eventually, the man dies. The newt's skin has tetrodotoxin in it. Tetrodotoxin is produced by rough-skinned newts as a form of defense against predation. Tetrodotoxin specifically blocks the sodium pore in voltage-gated sodium channels. It does not affect the gates of a voltage-gated sodium channel. The toxin has no other effects.We will use one bipolar neuron to answer the following questions. This neuron has a resting membrane potential of -65mV. 1) true/false While under the effect of tetrodotoxin, the man's neurons would be able to reach threshold potential at their initial segments. 2) true/false The man's neurons would not be able to fire EPSPs. 3) True/false: The man's neurons fired action potentials normally after a few minutes of licking the newt. 4)True/false All excitable cell membranes have leak channels.
The following questions apply to this information:A man licks a newt after being dared to do so by his boyfriend. Almost immediately, the man noticed that his lips and tongue felt numb. Within a few minutes, the man began to show a lack of coordination and skeletal muscle control. Within several more minutes, the man experienced difficulty breathing and symptoms of cardiac arrest. Eventually, the man dies. The newt's skin has tetrodotoxin in it. Tetrodotoxin is produced by rough-skinned newts as a form of defense against predation.
Tetrodotoxin specifically blocks the sodium pore in voltage-gated sodium channels. It does not affect the gates of a voltage-gated sodium channel. The toxin has no other effects.We will use one bipolar neuron to answer the following questions. This neuron has a resting membrane potential of -65mV.
1) true/false While under the effect of tetrodotoxin, the man's neurons would be able to reach threshold potential at their initial segments.
2) true/false The man's neurons would not be able to fire EPSPs.
3) True/false: The man's neurons fired action potentials normally after a few minutes of licking the newt.
4)True/false All excitable cell membranes have leak channels.
The newt or the rough-skinned newt (Taricha granulosa) is known for the production of a neurotoxin from its skin. This neurotoxin is called Tetrodotoxin. This neurotoxin is also produced by many pufferfish and marine animals. Tetrodotoxin is an inhibiter of sodium channels in the neurons and hence reduces the membrane excitability of muscle cells, cardiac muscles, and skeletal muscles.
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