A 28-year-old male was found unconscious in a bathtub full of ice by his roommate who took him to an emergency department. On admission he was conscious, but confused and hyperthermic with some muscle rigidity. He thought he had gotten food poisoning, but the symptoms have gotten progressively worse. His roommate reminds him that he also has been taking some body building supplements ordered from the internet. Toxicology reports were negative for alcohol and positive for 2,4-dinitrophenol, later confirmed to be from the supplements. 1. Based on this information, please summarize this individual's metabolic state at the time of presentation. Be sure to include: O Rates of oxygen consumption ■ ATP production Levels of mitochondrial NADH ■ An explanation for the increase in body temperature. 2. Discuss 2,4-dinitrophenol and how it impacts metabolism
A 28-year-old male was found unconscious in a bathtub full of ice by his roommate who took him to an emergency department. On admission he was conscious, but confused and hyperthermic with some muscle rigidity. He thought he had gotten food poisoning, but the symptoms have gotten progressively worse. His roommate reminds him that he also has been taking some body building supplements ordered from the internet. Toxicology reports were negative for alcohol and positive for 2,4-dinitrophenol, later confirmed to be from the supplements. 1. Based on this information, please summarize this individual's metabolic state at the time of presentation. Be sure to include: O Rates of oxygen consumption ■ ATP production Levels of mitochondrial NADH ■ An explanation for the increase in body temperature. 2. Discuss 2,4-dinitrophenol and how it impacts metabolism
Essentials of Pharmacology for Health Professions
7th Edition
ISBN:9781305441620
Author:WOODROW
Publisher:WOODROW
Chapter2: Drug Names And References
Section: Chapter Questions
Problem 11CRQ
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Transcribed Image Text:A 28-year-old male was found unconscious in a bathtub full of ice by his
roommate who took him to an emergency department. On admission he was
conscious, but confused and hyperthermic with some muscle rigidity. He thought
he had gotten food poisoning, but the symptoms have gotten progressively
worse. His roommate reminds him that he also has been taking some body
building supplements ordered from the internet.
Toxicology reports were negative for alcohol and positive for 2,4-dinitrophenol,
later confirmed to be from the supplements.
1. Based on this information, please summarize this individual's metabolic state at the time
of presentation.
Be sure to include:
O
■ Rates of oxygen consumption
ATP production
■ Levels of mitochondrial NADH
■
■ An explanation for the increase in body temperature.
2. Discuss 2,4-dinitrophenol and how it impacts metabolism
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