Given the fact that phenylalanine has a pK₂1-1.83 and pK a2-9.13, show the condensed structure of the dominant specie in solution at a. Determine the isoelectric point for valine. Show your work. b. pH=1.0 c.pH=11.0

Given the fact that phenylalanine has a pK₂1-1.83 and pK a2-9.13, show the condensed structure of the dominant specie in solution at a. Determine the isoelectric point for valine. Show your work. b. pH=1.0 c.pH=11.0

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

See similar textbooks

Related questions

Q: Calculate the isoelectric point of tyrosine using the pKa values in Table 4-1 of Voet, Voet and…

A: For isoelectric point calculation the pKa values of alpha-COOH = 2.20 pKa values of alpha-NH3+ =…

Q: Draw Fisher projection L form of amino acid Serine at physiological pH of 7.4. The following are the…

A: given pK1 = 2.21 pK2 = 9.15

Q: reconstruct the peptide sequence. M, 1-Letter Residue 71.0786 R. 156.1870 114.1036 115.0884 103.1386…

A: Solution: The polypeptide chain from N- to C- terminus is as follows.

Q: Determine the pl for this synthesized pentapeptide: A-B-C-D-E Given that the pK values for the amino…

A: We know if the pH is greater than pka, then deprotonation occurs and it exists in deprotonated form.…

Q: 50.0 mL of a 0.3M solution of the tetrapeptide Glu-Phe-Lys-Ser is adjusted to pH=4.8. The solution…

A: Millimoles of the tetrapeptide taken =Molar concentration of tetrapeptide×Volume of tetrapeptide=0.3…

Q: Modify the structure of the amino acid valine to complete the reactions corresponding to the…

A: Amino acids are organic molecules containing a central carbon atom with a carboxylic acid group, an…

Q: S ant ectr ทบ 27. Write the the noncovalent interactions that are possible for the side chains of…

A: Serine (S):Hydrogen Bonds: Serine has a hydroxyl group (-OH) in its side chain. This group can form…

Q: The electrospray ionization mass spectrum of the tripeptide Ala-Met-Thr shows peaks of…

A: Given peptide is: Ala-Met-Thr

Q: Identify the peaks of the 1D ¹H NMR and identify the amino acid at physiological pH. 10 Q K a.…

Q: Determine the pl for this synthesized pentapeptide: A-B-C-D-E Given that the pK values for the amino…

Q: Brucine is a poisonous alkaloid obtained from Strychnos nux vomica, a tree that grows in India, Sri…

A: Figure 1

Q: mcc powder contains 86.6% proteins and powder containg 93.4%. proteing. WPL Calculate the amount of…

A: MCC powder contains 86.6% protein, i.e. 100 g of MCC powder contains 86.6 g of protein Similarly,…

Q: Rank these basicities of the amine groups in these amino acids according to their expected pK,…

Q: Which of the following statements BEST describe the given chromatogram? Peaks 14, 18, 20 and…

A: To determine which statement best describes the given chromatogram.

Q: on derivative curves, there are several sharp peaks. what points in the ionisation of the amino acid…

A: 1. Derivative curve plots the change in pH divided by change in number of moles of the base added,…

Q: 8. The following proteins represent a wide range of molecular weights and isoelectric points. Mr is…

Q: 2. In what order would the following globular proteins emerge/eluted on gel filtration of a mixture…

A: Gel filtration technique elute or separate on the basis of molecular mass. Higher molecular mass…

Q: Please create the titration curve of aspartate and annotate the corresponding isoforms.

A: Amino acids are amphoteric in nature due to the presence their ionizable α-amino and α-carboxylic…

Q: Estimate the pI of a dipeptide Cys-Asp assuming that the pKa values for αα-NH3+, αα-COOH, side chain…

A: The question is based on the concept of peptides. we have to identify the isoelectric point of given…

Q: Determine the pl for this synthesized pentapeptide: A-8-C-D-E Given that the pk values for the amino…

A: A biomolecule having both acidic COOH group and basic NH2 group is knownas amino acid We are…

Q: sample question 2. During further studies on transferrin, the protein was treated with…

A: The above question is about biochemistry and analytical chemistry, specifically the characterisation…

Q: 2) Part of the 'H NMR spectrum for a dipeptide recorded in D₂O is shown below. The signal for the CH…

A: When molecules are placed in a strong magnetic field, the nuclei of some atoms will begin to behave…

Q: Explain the order of elution (with a buffer of pH 4) of the following pairs of amino acids through a…

Q: Show the 1H NMR spectrum for arginine

A: We have to show the 1H NMR spectrum for arginine as follows in step 2:

Q: Finally, you want to make completely certain that you purified the correct protein and not some…

A: To prepare a 500 mL solution of phosphate-buffered saline (PBS) with a pH of 8.0, a combination of…

Q: Consider a histidine residue within a protein. Based on the histidine side-chain pKa value of 6.0…

A: Histidine is a basic amino acid used to make up proteins which contain an amino group and a…

Q: 3-1. For each of the given amino acids, write the equilib- rium reactions that would apply at a pH…

A: Deprotonating of an acidic and protonated(with H+) takes place at a pH higher than the pKa value.…

Q: Find the pl of Glutamate. The alpha-carboxyl group's pKa is 2.19, the side-chain pKa is 4.25, and…

A: Given,The pKa of alpha⎯carboxyl group = 2.19 side⎯chain = 4.25…

Q: 3a. At right is a hypothetical enzyme that breaks down isoleucine (the amino acid substrate is shown…

Q: Produce a reading outline for the chapter on amino acids and the section that introduces the peptide…

A: Since you have asked multiple questions, we will solve the first question for you. For any…

Q: please answer

A: A. At neutral pH, the tri-prptide Phe -Gln-Ser is shown below :

Q: Show a detailed mechanism for the coupling of N-acetyl-L-proline to L-ValOBn using (a) DCC/HOBT

A: Amino acid consists an amino group and a carboxylic acid group and both the functional groups are…

Q: The side chain of acetyl-L-lysine-OMe has a pKa=10.5 and its acid-dissociation reaction is shown…

Q: The amino acid L-alanine has pKa values of its ionisable groups of 2.3 and 9.9. Which one of the…

Q: Why is glycine the only amino acid commonly observed in peptides inconformations with phi and psi…

Q: would chymotrypsin to be most active at a pH of 4.5, 7.8, or 10.0?

A: Chymotrypsin is an enzyme which is used for the digestion of protein. This enzyme is secreted by the…

Q: A Write the structure of the pentapeptide GL B. What is the complete name of this pentapeptide? Show…

A: A) Pentapeptide GLDSC contains five amino acids i.e, glycine, leucine, aspartic acid, serine, and…

Q: Chemistry help asap! will give you upvote! 7. What is the isoelectric point of the following…

A: #7: Isoelectric point is the average of the two pKa values that are close to each other.

Q: Determine the pl for this synthesized pentapeptide: A-B-C-D-E Given that the pK values for the amino…

A: Amino acid are biomolecules which have both acidic and and basic group We are required to find the…

Q: Rank the pKa values of the conjugate acids for nosylate, tosylate, and brosylate

A: A conjugate acid is the species that is formed when a base accepts a proton (H+) in a chemical…

Q: The following diagram illustrates the process of fragment-based drug discovery Binding site her…

A: In the development of drug, it is necessary that drug must be attached to binding site. Only a…

Q: 30. At what pH would you expect the aminoacid proline (P) to be fully protonated? pK₁ = 1.952, pK2 =…

A: #30: An acidic group remains in protonated form when pH < pKa value. Because at low pH there is…

Q: b) The methyl group at the C terminus of aspartame can be cleaved by concentrated sulfuric acid…

A: The isoelectric point (pI) is the pH at which the molecule carries no net electrical charge. At a pH…

Q: Chemistry Given TETRAPEPTIDE: Prolinyl-Argininyl-Cysteinyl-Tryptophan Predict the direction of the…

A: The given peptide according to the given sequence is: Proline makes the N terminal of the peptide.…

Q: The side chain of acetyl-L-lysine-OMe has a pKa=10.5 and its acid-dissociation reaction is shown…

Q: On the paper provided, draw the chemical structure of a peptide with a sequence YIQV at pH 14. The…

A: When two amino acids combine, they involve loss of water molecule. This is a type of condensation…

Concept explainers

Spectroanalytical Methods

Spectroanalytical methods measure the wavelength and intensity of radiations that are either emitted or absorbed by a molecular or atomic species. These methods are useful for evaluating the electronic or atomic arrangement of the molecules of a given analyte.

Question

Given the fact that phenylalanine has a pK₁1-1.83 and pK₂2-9.13, show the condensed structure of the
dominant specie in solution at
a. Determine the isoelectric point for valine. Show your work.
b. pH=1.0
c. pH=11.0

Expert Solution

This question has been solved!

Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.

SEE SOLUTION Check out a sample Q&A here

Step 1

Step 2

Step 3

Step 4

Step by step

Solved in 4 steps with 3 images

SEE SOLUTION Check out a sample Q&A here

Knowledge Booster

Learn more about

Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, chemistry and related others by exploring similar questions and additional content below.

Similar questions

The isoelectric point (pl) can best be calculated by: Averaging the sums of all pkas. Averaging the sum of the two pKas closest to physiological pH. Averaging the two pKas "sandwiching" the zwitterionic form. Averaging the two pKas of the alpha-amino and alpha-carboxy groups.
Calculate the average charge of the peptide KLMRDCP (pKa = 3.5, 3.9, 8.3, 9.5, 10.0, 12.5) at pH 7.40.
Calculate the percentage ionization (i.e. [base]/[acid]x100) in these amino acid side chains at the pH values specified (show your work for one of these amino acid chains): - Aspartate (pKa=4.1) at pH 5.4 - Arginine (pKa=12.5) at pH 11.8 - Histidine (pKa=6.0) at pH 8.0 - Tyrosine (pKa=10.9) at pH 8.0
Solve it asap
1 Submit Q10. !! Unanswered Q10. An average amino acid is about 110 Da (Daltons). If there are 1273 amino acids in the SARS-CoV-2 spike protein, what do you expect the mass of spike to be? How does that compare to the expected mass of about 200 KDa? more than expected by about 90 Da Less than expected by about 90 Da B. more than expected by by about 60 KDa less than expected by about 60 KDa Submit odf 0/11 answered
Please explain in depth. I understand it is a zwitterion but I need an in depth explanation. Thank you
18.18-Enhanced - with Feedback 4. Reset Help peptide bond a carbon a carbon HN-CH CNH-CH- peptide bond CH2 CH,COO CH,CHCH, R group 418 P 71°F A O 10/10/2 hp
The term used to separate a mixture of enantiomers of amino acids using chiral reagents? A) Thermodynamic resolution B) Meso resolution C) Kinetic Resolution D) Neutralization E) Isomeric resolution
How would you solve this?
NEED THOROUGH EXPLANATIONS ASAP WILL DEFINITELY UPVOTE
Could you help me with this? I'm stuck on this question.
Calculate the pl of arginine. Give your answer to two decimal places. pI =