GENETICS AND FAST-TWITCH MUSCLES The gene ACTN3 encodes a protein that functions in fast-twitch muscles. People can be classified according to which genotype of this gene they have, RR, RX, or XX, and also according to which genetic allele they have, R or X. The study¹ described here, examines the association between this gene and different subgroups of the population. All participants in the study live in Australia. The earlier exercises only included the control group. Gender and ACTN3 Genotype We know that sprinters are more likely to have allele R and genotype RR versions of the ACTN3 gene, which makes these versions associated with fast-twitch muscles. Is there an association between genotype and gender? Computer output is shown for this chi- square test, using the control group in the study. In each cell, the top number is the observed count, the middle number is the expected count, and the bottom number is the contribution to the chi-square statistic. What is the p-value? p-value = i Male Female RR 40 40.26 0.002 88 87.74 0.001 RX 73 128 69.20 0.208 147 150.80 0.096 XX 21 24.54 0.509 Total Chi-Sq = 1.050, DF = 2, P-Value = 0.592 220 57 53.46 0.234 78 Total 134 292 426

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GENETICS AND FAST-TWITCH MUSCLES
The gene ACTN3 encodes a protein that functions in fast-twitch muscles. People can be classified according to which genotype of this
gene they have, RR, RX, or XX, and also according to which genetic allele they have, R or X. The study¹ described here, examines the
association between this gene and different subgroups of the population. All participants in the study live in Australia. The earlier
exercises only included the control group.
Gender and ACTN3 Genotype
We know that sprinters are more likely to have allele R and genotype RR versions of the ACTN3 gene, which makes these versions
associated with fast-twitch muscles. Is there an association between genotype and gender? Computer output is shown for this chi-
square test, using the control group in the study. In each cell, the top number is the observed count, the middle number is the expected
count, and the bottom number is the contribution to the chi-square statistic.
What is the p-value?
p-value = i
Male
Female
RR
40
Total
40.26
0.002
88
87.74
0.001
RX
73
128
69.20
0.208
147
150.80
0.096
XX
21
220
78
Chi-Sq = 1.050, DF = 2, P-Value = 0.592
24.54
0.509
57
53.46
0.234
Total
134
292
426
Transcribed Image Text:GENETICS AND FAST-TWITCH MUSCLES The gene ACTN3 encodes a protein that functions in fast-twitch muscles. People can be classified according to which genotype of this gene they have, RR, RX, or XX, and also according to which genetic allele they have, R or X. The study¹ described here, examines the association between this gene and different subgroups of the population. All participants in the study live in Australia. The earlier exercises only included the control group. Gender and ACTN3 Genotype We know that sprinters are more likely to have allele R and genotype RR versions of the ACTN3 gene, which makes these versions associated with fast-twitch muscles. Is there an association between genotype and gender? Computer output is shown for this chi- square test, using the control group in the study. In each cell, the top number is the observed count, the middle number is the expected count, and the bottom number is the contribution to the chi-square statistic. What is the p-value? p-value = i Male Female RR 40 Total 40.26 0.002 88 87.74 0.001 RX 73 128 69.20 0.208 147 150.80 0.096 XX 21 220 78 Chi-Sq = 1.050, DF = 2, P-Value = 0.592 24.54 0.509 57 53.46 0.234 Total 134 292 426
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