Fundamentals of Biostatistics | (8th Edition) Chapter 10, Problem 17P Problem Bookmark Show all steps: ON The conventions of cardiac echocardiography are derived from comprehensive studies performed by technicians and cardiologists. Traditionally, patients are positioned supine (i.e., lying on their back), although there is no evidence to support this practice. Clinicians in the emergency department (ED) are sometimes faced with acutely ill patients who cannot tolerate the supine position. For this reason, a study is planned to compare ultrasound studies performed while a patient is supine vs. while a patient is upright. Patients 218 years of age who present to the ED with chest pain or shortness of breath and consent to the study will be enrolled. Each patient will receive two ultrasound studies, one in the supine position and one in the upright position. The order of administration of the two studies will be at random. Readers will review the images in a blinded manner and assess a number of clinical characteristics. An important endpoint is pericardial effusion (or fluid around the heart). Suppose 50 patients are enrolled in the pilot phase of the study. (i) For 30 patients it is determined from both images that there is no fluid around the heart. (ii) For 10 patients it is determined from both images that there is fluid around the heart. (iii) For 8 patients it is determined from the supine image, but not the upright image, that there is fluid around the heart. (iv) For 2 patients it is determined from the upright image, but not the supine image, that there is fluid around the heart. D. If we focus on patients where there are different results for the supine and upright images [i.e., groups (iii) and (iv) above], what test can be performed to assess whether there is a significant difference in determinations for supine vs. upright images? 10.18 Perform the test in Problem 10.17 and report a p-value (two-tailed). Interpret the results in words.
Fundamentals of Biostatistics | (8th Edition) Chapter 10, Problem 17P Problem Bookmark Show all steps: ON The conventions of cardiac echocardiography are derived from comprehensive studies performed by technicians and cardiologists. Traditionally, patients are positioned supine (i.e., lying on their back), although there is no evidence to support this practice. Clinicians in the emergency department (ED) are sometimes faced with acutely ill patients who cannot tolerate the supine position. For this reason, a study is planned to compare ultrasound studies performed while a patient is supine vs. while a patient is upright. Patients 218 years of age who present to the ED with chest pain or shortness of breath and consent to the study will be enrolled. Each patient will receive two ultrasound studies, one in the supine position and one in the upright position. The order of administration of the two studies will be at random. Readers will review the images in a blinded manner and assess a number of clinical characteristics. An important endpoint is pericardial effusion (or fluid around the heart). Suppose 50 patients are enrolled in the pilot phase of the study. (i) For 30 patients it is determined from both images that there is no fluid around the heart. (ii) For 10 patients it is determined from both images that there is fluid around the heart. (iii) For 8 patients it is determined from the supine image, but not the upright image, that there is fluid around the heart. (iv) For 2 patients it is determined from the upright image, but not the supine image, that there is fluid around the heart. D. If we focus on patients where there are different results for the supine and upright images [i.e., groups (iii) and (iv) above], what test can be performed to assess whether there is a significant difference in determinations for supine vs. upright images? 10.18 Perform the test in Problem 10.17 and report a p-value (two-tailed). Interpret the results in words.
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![Fundamentals of Biostatistics | (8th Edition)
0
MAKANAN
Chapter 10, Problem 17P
10.18
Problem
Bookmark
Show all steps: ON
The conventions of cardiac echocardiography are derived from comprehensive studies
performed by technicians and cardiologists. Traditionally, patients are positioned supine (i.e.,
lying on their back), although there is no evidence to support this practice. Clinicians in the
emergency department (ED) are sometimes faced with acutely ill patients who cannot tolerate
the supine position. For this reason, a study is planned to compare ultrasound studies performed
while a patient is supine vs. while a patient is upright.
Patients 218 years of age who present to the ED with chest pain or shortness of breath and
consent to the study will be enrolled. Each patient will receive two ultrasound studies, one in the
supine position and one in the upright position. The order of administration of the two studies will
be at random. Readers will review the images in a blinded manner and assess a number of
clinical characteristics. An important endpoint is pericardial effusion (or fluid around the heart).
Suppose 50 patients are enrolled in the pilot phase of the study.
(i) For 30 patients it is determined from both images that there is no fluid around the heart.
(ii) For 10 patients it is determined from both images that there is fluid around the heart.
(iii) For 8 patients it is determined from the supine image, but not the upright image, that there is
fluid around the heart.
(iv) For 2 patients it is determined from the upright image, but not the supine image, that there is
fluid around the heart.
D. If we focus on patients where there are different results for the supine and upright images [i.e.,
groups (iii) and (iv) above], what test can be performed to assess whether there is a significant
difference in determinations for supine vs. upright images?
K
**
Perform the test in Problem 10.17 and report a p-value (two-tailed).
Interpret the results in words.
Please help.](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2Faeadb183-1175-48ee-be1d-be4cbd36e1e9%2F5e484b8b-b4ce-4d90-9872-0063a360e360%2Fvyid60k_processed.jpeg&w=3840&q=75)
Transcribed Image Text:Fundamentals of Biostatistics | (8th Edition)
0
MAKANAN
Chapter 10, Problem 17P
10.18
Problem
Bookmark
Show all steps: ON
The conventions of cardiac echocardiography are derived from comprehensive studies
performed by technicians and cardiologists. Traditionally, patients are positioned supine (i.e.,
lying on their back), although there is no evidence to support this practice. Clinicians in the
emergency department (ED) are sometimes faced with acutely ill patients who cannot tolerate
the supine position. For this reason, a study is planned to compare ultrasound studies performed
while a patient is supine vs. while a patient is upright.
Patients 218 years of age who present to the ED with chest pain or shortness of breath and
consent to the study will be enrolled. Each patient will receive two ultrasound studies, one in the
supine position and one in the upright position. The order of administration of the two studies will
be at random. Readers will review the images in a blinded manner and assess a number of
clinical characteristics. An important endpoint is pericardial effusion (or fluid around the heart).
Suppose 50 patients are enrolled in the pilot phase of the study.
(i) For 30 patients it is determined from both images that there is no fluid around the heart.
(ii) For 10 patients it is determined from both images that there is fluid around the heart.
(iii) For 8 patients it is determined from the supine image, but not the upright image, that there is
fluid around the heart.
(iv) For 2 patients it is determined from the upright image, but not the supine image, that there is
fluid around the heart.
D. If we focus on patients where there are different results for the supine and upright images [i.e.,
groups (iii) and (iv) above], what test can be performed to assess whether there is a significant
difference in determinations for supine vs. upright images?
K
**
Perform the test in Problem 10.17 and report a p-value (two-tailed).
Interpret the results in words.
Please help.
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