Progesterone is a steroid hormone (also described as a ligand) that prepares the bodyfor pregnancy. It binds to the progesterone receptor (PR) protein in the cytoplasm ofvarious cells.Ligand bound PR acts as a transcriptional activator, binds to the DNA in thepromoter region of several genes and leads to transcriptional activation of thesegenes.Ligand bound PR has been shown to increase the expression of a gene, FKBP5.You are studying the activity of wild-type (WT) and mutant PR in cells by examiningexpression of FKBP5. Results are obtained as shown in the figure below, where theasterisk indicates when progesterone was (or was not) added to the cells.From the results, which of the following statements can be concluded?WT PR without progesteroneWT PR with progesteroneTimeTimemutant PR without progesteronemutant PR with progesteroneTimeTimeThe wild-type PR is unable to increase FKBP5 expression in the absence ofligandThe wild-type PR increases FKBP5 expression after ligand bindingThe mutant PR shows no increase in FKBP5 expression on ligand bindingThe mutant PR is constitutively active, independent of ligand bindingFKBP5 gene expressionFKBP5 gene expressionFKBP5 gene expressionFKBP5 gene expression

Name: Progesterone is a steroid hormone (also described as a ligand) that p
Uploaded: 2024-03-20T06:42:55.000Z
Channel: Bartleby
Description: Progesterone is a steroid hormone (also described as a ligand) that prepares the bodyfor pregnancy. It binds to the progesterone receptor (PR) protein in the cytoplasm ofvarious cells.Ligand bound PR acts as a transcriptional activator, binds to the