For nucleophilic attack on a carbonyl in the substrate, an enzyme uses the deprotonated thiolate of cysteine. At pH 7.0, 9% of the enzyme is active, which correlates with the ionization state of cysteine. If the ratio of active to inactive enzyme is 1:10, what is the pka of the active site cysteine? а. 6.0 p. 6.5 c. 7.0 d. 7.5 е. 8.0 f. 8.5
For nucleophilic attack on a carbonyl in the substrate, an enzyme uses the deprotonated thiolate of cysteine. At pH 7.0, 9% of the enzyme is active, which correlates with the ionization state of cysteine. If the ratio of active to inactive enzyme is 1:10, what is the pka of the active site cysteine? а. 6.0 p. 6.5 c. 7.0 d. 7.5 е. 8.0 f. 8.5
Chapter10: Reconstitution Of Powdered Drugs
Section: Chapter Questions
Problem 30SST
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![For nucleophilic attack on a carbonyl in the substrate,
an enzyme uses the deprotonated thiolate of
cysteine. At pH 7.0, 9% of the enzyme is active, which
correlates with the ionization state of cysteine. If the
ratio of active to inactive enzyme is 1:10, what is the
pka of the active site cysteine?
а. 6.0
5. 6.5
C. 7.0
d. 7.5
е. 8.0
f. 8.5](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2Fdd49b60e-9843-47a5-8b5d-3f3394f78711%2F18eaf4b8-1f45-4b5f-9126-953040adb158%2Fnn6gjai_processed.jpeg&w=3840&q=75)
Transcribed Image Text:For nucleophilic attack on a carbonyl in the substrate,
an enzyme uses the deprotonated thiolate of
cysteine. At pH 7.0, 9% of the enzyme is active, which
correlates with the ionization state of cysteine. If the
ratio of active to inactive enzyme is 1:10, what is the
pka of the active site cysteine?
а. 6.0
5. 6.5
C. 7.0
d. 7.5
е. 8.0
f. 8.5
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