The enzyme lysozyme hydrolyzes glycosidic bonds in peptidoglycan, an oligosaccharide found ir bacterial cell walls. The active site of lysozyme contains two amino acid residues essential for catalysis: E35 and D52. Which of the following statements about lysozyme is true? More than one may apply The graph shows the pH-activity profile of lysozyme. 100 6. 8. 10 pH Residue E35 exhibits general base catalysis The pKa of E35 is approximately 4.3 O The pKa of D52 is approximately 4.5 The optimal activity of lysozyme is approximately 5.2 Residue E35 exhibits covalent catalysis The pKa of E35 is approximately 6.1 The pKa of D52 is approximately 3.7 Activity (% of maximal)
The enzyme lysozyme hydrolyzes glycosidic bonds in peptidoglycan, an oligosaccharide found ir bacterial cell walls. The active site of lysozyme contains two amino acid residues essential for catalysis: E35 and D52. Which of the following statements about lysozyme is true? More than one may apply The graph shows the pH-activity profile of lysozyme. 100 6. 8. 10 pH Residue E35 exhibits general base catalysis The pKa of E35 is approximately 4.3 O The pKa of D52 is approximately 4.5 The optimal activity of lysozyme is approximately 5.2 Residue E35 exhibits covalent catalysis The pKa of E35 is approximately 6.1 The pKa of D52 is approximately 3.7 Activity (% of maximal)
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Transcribed Image Text:The enzyme lysozyme hydrolyzes glycosidic bonds in peptidoglycan, an oligosaccharide found in
bacterial cell walls. The active site of lysozyme contains two amino acid residues essential for
catalysis: E35 and D52.
Which of the following statements about lysozyme is true? More than one may apply
The graph shows the pH-activity profile of lysozyme.
100
50
4.
6.
8.
10
pH
Residue E35 exhibits general base catalysis
O The pKa of E35 is approximately 4.3
O The pKa of D52 is approximately 4.5
O The optimal activity of lysozyme is approximately 5.2
Residue E35 exhibits covalent catalysis
The pka of E35 is approximately 6.1
The pka of D52 is approximately 3.7
Activity (% of maximal)
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