Fast forward 10 years, and you are working as a dermatologist specializing on hands. You notice almost all your patients who have nail patella syndrome (N: disease; n: wild-type) are also O blood type (genotype at the ABO gene: OO). Seems like a weird coincidence, until you remember that the genes causing these two traits are linked and 10 cM apart. If someone who is NBnO has children with someone who is NBnO, what is the probability they would have a kid without nail patella syndrome who is also B-blood type (genotype: BB).
Fast forward 10 years, and you are working as a dermatologist specializing on hands. You notice almost all your patients who have nail patella syndrome (N: disease; n: wild-type) are also O blood type (genotype at the ABO gene: OO). Seems like a weird coincidence, until you remember that the genes causing these two traits are linked and 10 cM apart. If someone who is NBnO has children with someone who is NBnO, what is the probability they would have a kid without nail patella syndrome who is also B-blood type (genotype: BB).
a. What is heritability, and what does it measure?
b. Would you do a GWAS on a trait with heritability of 0? Why or why not?
c. The effect sizes for the SNPs linked to performance on IQ tests are very very small. Why does that make it unlikely that we can genetically engineer humans with super high IQ?
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