Family in which one parent had dwarfism Children with Children with normal stature dwarfism A 15 B 4 D 6. 2 E 2 8. 4. 4 н I 3 к 2 3 2 м 2 N Total 52 40 o ON Men O Women 1O Dwarfism IV IV VII dapóppo
In the 1800s, a man with dwarfism who lived in Utah produced a large number of descendants: 22 children, 49 grandchildren, and 250 greatgrandchildren (see the illustration of a family pedigree to the right), many of whom also exhibited dwarfism (F. F. Stephens. 1943. Journal of Heredity 34:229–235). The type of dwarfism found in this family is called Schmid-type metaphyseal chondrodysplasia, although it was originally thought to be achondroplastic dwarfism. Among the families of this kindred, dwarfism appeared only in members who had one parent with dwarfism. When one parent exhibited dwarfism, the following numbers of children were produced.
Q. Use chi-square tests to determine if the numbers of children with each
different from the numbers expected on the basis of your proposed mode of inheritance. How would you explain these deviations from the overall ratio expected?
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