A rare blinding disease that has a relation to dengenerative factors is partially penetrant. In the following pedigrees for two families, the affected symptomatic individuals (black circles and squares) have been diagnosed with this disease due to the mutation in mitochondrial DNA m.14484T>C. If III.4 is homoplasmic for m.14484T>C in hair, blood, urine and other tissues examined. What will occur with IV.7 then? This image shows a genetic pedigree chart labeled as "A" with two family lines, Family I and Family II.**Explanation of the Pedigree Chart:**- **Symbols:** - Squares represent males. - Circles represent females. - Filled (black) symbols indicate individuals affected by a certain genetic trait. - Half-filled symbols represent carriers of the trait. - Diagonal lines through a symbol indicate a deceased individual.- **Family I:** - Starts with a couple in the first generation (I.2). - Second generation includes two affected females (II.3) and (III.4). - The fourth generation shows multiple affected males (IV.7).- **Family II:** - Begins with an individual who is deceased, indicated by a diagonal line in the first generation. - Second generation contains a mix of affected and unaffected individuals, marked by (II.1) and (II.2). - Third generation includes (III.1) and (III.3) with relevant annotations (A, G) indicating specific genetic information. - The fourth generation has both affected and unaffected individuals.- **Annotations:** - The letters (A, G) next to some individuals may refer to genetic markers or specific allele information related to the analysis.This chart is likely used to track the inheritance of a genetic trait across generations, helping to identify patterns and carriers within the families.

Name: A rare blinding disease that has a relation to dengenerative factors i
Uploaded: 2024-03-20T06:42:55.000Z
Channel: Bartleby
Description: A rare blinding disease that has a relation to dengenerative factors is partially penetrant. In the following pedigrees for two families, the affected symptomatic individuals (black circles and squares) have been diagnosed with this disease due to th