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Explain how our understanding of the molecular basis of cancer has been used to develop new approaches to treat cancer

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter12: Genes And Cancer

Section12.10: Genomics, Epigenetics,and Cancer

Problem 2GR: Another model, the random model, proposes that any cell in a malignant tumor has the potential to...

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Genomic studies

Genomic studies (genomics) is the study of the whole genome of an organism. Using bioinformatics and high-performance computing, genomic researchers examined massive amounts of deoxyribonucleic acid (DNA)-sequence data to discover variations or mutations that affect drug response, health, or disease. Genomics is a much younger discipline than genetics, having only emerged in the last few decades as a result of technological advancements in DNA sequencing and computational biology.

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Sequencing the human genome, the development of microarray technology, and personal genomics promise to improve our understanding of normal and abnormal cell behavior. How are these approaches dramatically changing our understanding and treatment of complex diseases such as cancer?
Explain how nanotechnology can be used to control cancer?
Drivers are mutations that drive the cancer process; passengers are mutations that arise randomly in the process of tumor development and do not contribute to the progression of cancer. How might researchers go about distinguishing between drivers and passengers? Propose some different approaches.
You have decided to combine your love of biology and your love of dogs to train dogs to detect cancer. You can reliably train dogs to detect cancer with a high degree of accuracy. The dogs are able to detect the cancer simply by sniffing clothing that had been worn by the patient and so there is no contact between the dog and the patient. Since there are no risks from the test, and you know that cancer caught early is often treatable you are keen to develop your idea further. What possible negative consequences would need to be considered before concluding that this type of screening test should be more widely used? You may select more than one answer. a. Risks associated with further tests such as biopsies to type and stage the cancer. b. Risks associated with surgical interventions to remove the cancer. C. Risks associated with chemotherapy used post surgery.
Hi, can you elaborate about these two concepts: 1) Can telomere inhibition be good cancer treatment? 2) Can cancer steam cells hypothesis be a good / bad approach?
Discuss the use of gene therapy in treating cancer.
Different gene therapy approaches have been studied for cancer gene therapy. These approaches include? (select all that applies) a.immunotherapy, b. anti-angiogenic gene therapy, c.inhibition of tumor invasion, d.induction of apoptosis
What are the biggest challenges that mutations pose to oncologists and cancer biologists who seek to find novel cures against cancers?
1) What are the limitations of targeted versus whole-genome or whole-exome profiling of cancer mutations? 2) What can you infer about mutations that are common to almost all of the cells in a tumor? 3) Summarize the high-level differences between the VCF and MAF file formats. 4) How do germline and somatic mutations differ in terms of their effect on cancer risk and prognosis?
How can researchers pinpoint the particular driver mutations most responsible for the cancer phenotype?
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Because cancer cells do not normally die, does this imply that if people attempted to extend their lives, it would most likely be through the employment of cancer cells? Could cancer be used as a vector to modify cells or shape it into what is desired?