EUKARYOTIC RNA POLYMERASE TRANSCRIPTION FACTORS Rather than just a sigma factor to recognize the promoter in conjunction with the pol recognized by a multi-subunit complex called transcription factor (TBP) and several TBP-associated factors (TAFS) wherein binding occurs independent transcription factors are needed. TF attaches to the TFIID while stabilizing the complex. TFIIF attaches to TFIID and TFIIB to allow docking of the RNA begin transcription: two more factors are required. TF binds TFII attaches to RNA Polymerase lI, providing a helicase activity need allow the polymerase to read one of them. TF also has another c phosphorylates RŅA polymerase Il's carboxyl-terminal domain (CTD). The CTD conta successively phosphorylated, forma (negatively charged) tail that aids in the separatic

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Substance Abuse

Substance abuse refers to the use of illegal drugs in excessive quantities, as well as the misuse of legal substances such as prescription or over-the-counter pharmaceuticals or alcohol for purposes other than those intended. Drug addiction, also known as substance use disorder, is a disease that affects the brain and behavior of a person. It leads to a failure to control the use of any drug or prescription, legal or illegal.