Esterase hydrolyzes ester bonds. For simplicity, only the amino acids whose side-chainsinteract with the substrate are shown. Each circled interaction is important for the bindingof the substrate to the enzyme.substratex CH,-OCH ZH3CCH, H,CCH,Esteraseactive siteFull activity of esterase is observed at 37°C and a pH of 7.4. You isolate the active form ofesterase, subject it to a high salt (high sodium chloride) concentration and show that it cannot bindthe substrate. You then return the sample to the original conditions and measure the substratebinding ability of the esterase again.Would the esterase bind to its substrate when returned to the pretreatment conditions(Yes/No)? Explain.

Ans. Yes. Yes, the esterase will most likely bind to the substrate when returned to the…

Esterase hydrolyzes ester bonds. For simplicity, only the amino acids whose side-chains interact with the substrate are shown. Each circled interaction is important for the binding of the substrate to the enzyme. substrate x LCH- CH, CH Z CH, H,C CH, H3C. Esterase active site

Esterase hydrolyzes ester bonds. For simplicity, only the amino acids whose side-chains interact with the substrate are shown. Each circled interaction is important for the binding of the substrate to the enzyme. substrate x LCH- CH, CH Z CH, H,C CH, H3C. Esterase active site

Chemistry

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Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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Vitamins and Coenzymes

A class of organic compounds needed in the human body for normal activities is known as vitamins. They are characterized into two parts depending upon their solubility in water. They can act as coenzymes, cofactors, or prosthetic groups for enzymes.

Question

Esterase hydrolyzes ester bonds. For simplicity, only the amino acids whose side-chains
interact with the substrate are shown. Each circled interaction is important for the binding
of the substrate to the enzyme.
substrate
x CH,-O
CH Z
H3C
CH, H,C
CH,
Esterase
active site
Full activity of esterase is observed at 37°C and a pH of 7.4. You isolate the active form of
esterase, subject it to a high salt (high sodium chloride) concentration and show that it cannot bind
the substrate. You then return the sample to the original conditions and measure the substrate
binding ability of the esterase again.
Would the esterase bind to its substrate when returned to the pretreatment conditions
(Yes/No)? Explain.

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