Esterase hydrolyzes ester bonds. For simplicity, only the amino acids whose side-chains interact with the substrate are shown. Each circled interaction is important for the binding of the substrate to the enzyme. substrate x LCH- CH, CH Z CH, H,C CH, H3C. Esterase active site
Esterase hydrolyzes ester bonds. For simplicity, only the amino acids whose side-chains interact with the substrate are shown. Each circled interaction is important for the binding of the substrate to the enzyme. substrate x LCH- CH, CH Z CH, H,C CH, H3C. Esterase active site
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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Transcribed Image Text:Esterase hydrolyzes ester bonds. For simplicity, only the amino acids whose side-chains
interact with the substrate are shown. Each circled interaction is important for the binding
of the substrate to the enzyme.
substrate
x CH,-O
CH Z
H3C
CH, H,C
CH,
Esterase
active site
Full activity of esterase is observed at 37°C and a pH of 7.4. You isolate the active form of
esterase, subject it to a high salt (high sodium chloride) concentration and show that it cannot bind
the substrate. You then return the sample to the original conditions and measure the substrate
binding ability of the esterase again.
Would the esterase bind to its substrate when returned to the pretreatment conditions
(Yes/No)? Explain.
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