32. Although most enzymes are quite specific, they can catalyze side reactions with compounds that are structurally similar to their physiological substrates, but usually at much slower rates. For example, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), which normally catalyzes the oxidative phosphorylation of glyceraldehyde-3-phosphate, can slowly convert erythrose-4-phosphate, an intermediate in the pentose phosphate pathway, to 1,4-bisphosphoerythronate: OPO² H-C-OH X H-C-OH + NADP: H.C-OPO, GAPDH H-C-CH H-C-OH H₂C-OPO +NADH + H²

32. Although most enzymes are quite specific, they can catalyze side reactions with compounds that are structurally similar to their physiological substrates, but usually at much slower rates. For example, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), which normally catalyzes the oxidative phosphorylation of glyceraldehyde-3-phosphate, can slowly convert erythrose-4-phosphate, an intermediate in the pentose phosphate pathway, to 1,4-bisphosphoerythronate: OPO² H-C-OH X H-C-OH + NADP: H.C-OPO, GAPDH H-C-CH H-C-OH H₂C-OPO +NADH + H²

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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Concept explainers

Organic Chemistry of Metabolic Pathways

Metabolic pathways allude to the arrangement of chemical catalyzed reactions that lead to the transformation of a substance into the final product. Metabolic pathways incorporate a progression of reaction where the substrate is changed continuously and the transitional metabolites are persistently recovered.

Glucogenesis

Glucogenesis is a metabolic pathway in which glucose is produced from carbon substrates that are not carbohydrates. This process is observed in plants, animals, fungi, bacteria and other micro organisms. The general definition for glucogenesis or gluconeogenesis is as follows,

Question

32. Although most enzymes are quite specific, they can catalyze
side reactions with compounds that are structurally similar to
their physiological substrates, but usually at much slower rates.
For example, glyceraldehyde-3-phosphate dehydrogenase
(GAPDH), which normally catalyzes the oxidative
phosphorylation of glyceraldehyde-3-phosphate, can slowly
convert erythrose-4-phosphate, an intermediate in the pentose
phosphate pathway, to 1,4-bisphosphoerythronate:
H
OPO²
H-C-OH
H-C-OH
+NAD
HLC-OPO.
Erythrose-4-
phosphate
GAPDH H-C-CH
H-CHOH
+NADH + H²
H.C-OPO.
1,4-Bisphosphoerythronate

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