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Epinephrine B-Adrenergic receptor α В Figure 13.04 Biochemistry, Third Edition 2015 W.H. Freeman and Company ATP Adenylate cyclase Protein kinase A Cyclic AMP ↓ Protein kinase A 1. What type of receptor is this? 2. Is it a integral protein, peripheral protein, GPI linked protein? 3. What are the characteristics of membrane proteins? 4. Which Ga protein activates adenylyl cyclase? 5. Which form of the Ga protein is active (GTP bound or GDP bound)? 6. When does Ga re-associate with the beta and gamma G proteins? 7. What is the secondary messenger produced from the activation of adenylyl cyclase? Proliferation Migration

Epinephrine B-Adrenergic receptor α В Figure 13.04 Biochemistry, Third Edition 2015 W.H. Freeman and Company ATP Adenylate cyclase Protein kinase A Cyclic AMP ↓ Protein kinase A 1. What type of receptor is this? 2. Is it a integral protein, peripheral protein, GPI linked protein? 3. What are the characteristics of membrane proteins? 4. Which Ga protein activates adenylyl cyclase? 5. Which form of the Ga protein is active (GTP bound or GDP bound)? 6. When does Ga re-associate with the beta and gamma G proteins? 7. What is the secondary messenger produced from the activation of adenylyl cyclase? Proliferation Migration

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Epinephrine α GDP B B-Adrenergic receptor Figure 13.04 Biochemistry, Third Edition 2015 W.H. Freeman and Company Y KOMA Adenylate cyclase GTP ATP Protein kinase A Cyclic AMP ↓ W Protein kinase A 1. What type of receptor is this? 2. Is it a integral protein, peripheral protein, GPI linked protein? 3. What are the characteristics of membrane proteins? 4. Which Ga protein activates adenylyl cyclase? 5. Which form of the Ga protein is active (GTP bound or GDP bound)? 6. When does Ga re-associate with the beta and gamma G proteins? 7. What is the secondary messenger produced from the activation of adenylyl cyclase? Proliferation Migration
Transcribed Image Text:Epinephrine α GDP B B-Adrenergic receptor Figure 13.04 Biochemistry, Third Edition 2015 W.H. Freeman and Company Y KOMA Adenylate cyclase GTP ATP Protein kinase A Cyclic AMP ↓ W Protein kinase A 1. What type of receptor is this? 2. Is it a integral protein, peripheral protein, GPI linked protein? 3. What are the characteristics of membrane proteins? 4. Which Ga protein activates adenylyl cyclase? 5. Which form of the Ga protein is active (GTP bound or GDP bound)? 6. When does Ga re-associate with the beta and gamma G proteins? 7. What is the secondary messenger produced from the activation of adenylyl cyclase? Proliferation Migration
1. Which G protein activates Phospholipase C (PLC)? 2. What phospholipid does PLC cleave to produce second messengers? 3. What are the properties of these 2 second messengers? 4. Which second messenger opens a ligand gated ion channel in the ER? 5. Which hydrophobic second messenger activates protein kinase C? 6. Which hydrophilic second messenger activates protein kinase C by increasing cytosolic Ca2+ levels which allows Ca2+ to bind to PKC? Kinases PI 3-kinase 2 Phosphatidylinositol (PI) PI 4,5-bis-phosphate (PI-4,5-bisP) PLC Plasma membrane domains 0000 Diacylglycerol (DAG) Inositol 1,4,5-tris-phosphate (IP₂) Second messengers PI 3,4,5-tris-phosphate (PI-3,4,5-trisP) Docking site for pleckstrin homology H Cell membrane PIP 2 Phospholipase C cleavage IP 3 ER membrane ay Calcium ion Calcium ion Figure 13.12 Biochemistry, Third Edition 2015 W.H. Freeman and Company Diacylglycerol (DAG) DAGI TAKMINMA Protein kinase C IP3 receptor Cytoplasm MINIM
Transcribed Image Text:1. Which G protein activates Phospholipase C (PLC)? 2. What phospholipid does PLC cleave to produce second messengers? 3. What are the properties of these 2 second messengers? 4. Which second messenger opens a ligand gated ion channel in the ER? 5. Which hydrophobic second messenger activates protein kinase C? 6. Which hydrophilic second messenger activates protein kinase C by increasing cytosolic Ca2+ levels which allows Ca2+ to bind to PKC? Kinases PI 3-kinase 2 Phosphatidylinositol (PI) PI 4,5-bis-phosphate (PI-4,5-bisP) PLC Plasma membrane domains 0000 Diacylglycerol (DAG) Inositol 1,4,5-tris-phosphate (IP₂) Second messengers PI 3,4,5-tris-phosphate (PI-3,4,5-trisP) Docking site for pleckstrin homology H Cell membrane PIP 2 Phospholipase C cleavage IP 3 ER membrane ay Calcium ion Calcium ion Figure 13.12 Biochemistry, Third Edition 2015 W.H. Freeman and Company Diacylglycerol (DAG) DAGI TAKMINMA Protein kinase C IP3 receptor Cytoplasm MINIM
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