Empty MHC class I and MHC class II molecules are rapidly removed from the cell surface. This process prevents: The accumulation of empty MHC molecules on the cell surface which would interfere with T cells recognizing pathogen-derived peptide:MHC complexes Pathogens from evading the immune response by inducing peptide release from cell surface MHC molecules MHC class I molecules from being internalized into endosomes and binding endosome-derived peptides HLA-DM from trafficking to the cell surface with MHC class II Inappropriate T cell recognition of healthy cells that are not infected, nor have ingested a pathogen

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Empty MHC class I and MHC class II molecules are rapidly removed from the cell surface. This process prevents:

  1. The accumulation of empty MHC molecules on the cell surface which would interfere with T cells recognizing pathogen-derived peptide:MHC complexes
  2. Pathogens from evading the immune response by inducing peptide release from cell surface MHC molecules
  3. MHC class I molecules from being internalized into endosomes and binding endosome-derived peptides
  4. HLA-DM from trafficking to the cell surface with MHC class II
  5. Inappropriate T cell recognition of healthy cells that are not infected, nor have ingested a pathogen
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