Electroconvulsive therapy (ECT) is a reasonable option for intractable depression or schizophrenia, but a mechanism of action has not been established. One credible hypothesis is related to neural plasticity. Below is the neuronal gene expression assay for four genes after ECT, normalized with the Hamilton depression rating scale of 21 items version (HAM-D-21). Which of the following conclusion you may NOT conclude from the data?ECT may convert adult neurons into IPSCs which may divide and differentiate into healthy adult neuronsNeural plasticity steadily increases with the number of ECT administrationECT seems to increase the expression of Yamanaka’s four transcription factorsECT may increase neural plasticity HAM-D 213.532.521.510.50Before ECT 3rd ECT6th ECT10th ECTKLF4 (n=10)MYC (n=12)OCT4 (n=10)SOX2 (n=11)

The data provided in the neuronal gene expression assay, along with the Hamilton depression rating…

Answered: Electroconvulsive therapy (ECT) is a…

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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Electroconvulsive therapy (ECT) is a reasonable option for intractable depression or schizophrenia, but a mechanism of action has not been established. One credible hypothesis is related to neural plasticity. Below is the neuronal gene expression assay for four genes after ECT, normalized with the Hamilton depression rating scale of 21 items version (HAM-D-21). Which of the following conclusion you may NOT conclude from the data?

ECT may convert adult neurons into IPSCs which may divide and differentiate into healthy adult neurons
Neural plasticity steadily increases with the number of ECT administration
ECT seems to increase the expression of Yamanaka’s four transcription factors
ECT may increase neural plasticity

HAM-D 21
3.5
3
2.5
2
1.5
1
0.5
0
Before ECT 3rd ECT
6th ECT
10th ECT
KLF4 (n=10)
MYC (n=12)
OCT4 (n=10)
SOX2 (n=11)

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