EGF-R path o Discuss how the EGF-R becomes active o How does the active receptor recruit substrate, and how does substrate hold onto receptor? When held, what “options” in regards to what the receptor does to bound substrate? o What proteins are involved in the recruitment of ras to the receptor, and how does ras become active – what does it do then? Make sure you include the G-protein story.
EGF-R path o Discuss how the EGF-R becomes active o How does the active receptor recruit substrate, and how does substrate hold onto receptor? When held, what “options” in regards to what the receptor does to bound substrate? o What proteins are involved in the recruitment of ras to the receptor, and how does ras become active – what does it do then? Make sure you include the G-protein story.
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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EGF-R path
o Discuss how the EGF-R becomes active
o How does the active receptor recruit substrate, and how does substrate hold onto
receptor? When held, what “options” in regards to what the receptor does to
bound substrate?
o What proteins are involved in the recruitment of ras to the receptor, and how does
ras become active – what does it do then? Make sure you include the G-protein
story.
o When active, ras triggers the MAPK cascade – what is the end result of this path.
o Discuss the most common mutation in the ras gene found in cancer cells – how does
this mutation play a role in the cancer cell story?
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