Draw the structures of the compounds mentioned in the questions below. Circle the functional group that can be ionized You must show your calculations. Benzoic acid has a pK₁ of 4.20. If it is present in urine that has a pH of 5.68, what is the ratio of the concentrations of the ionized to un-ionized chemical?

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Draw the structures of the compounds mentioned in the questions below. Circle the functional
group that can be ionized
You must show your calculations.
Benzoic acid has a pKa of 4.20. If it is present in urine that has a pH of 5.68, what is the ratio of
the concentrations of the ionized to un-ionized chemical?
Calculate the fraction of the total amount of benzoic acid that is ionized in the urine.
Aniline has a pKa of 4.6. If it is present in urine that has a pH of 5.45, what is the percentage of
aniline that is ionized in the urine?
A chemical is subjected to a partition coefficient measurement using 1-octanol and water. After
equilibration and separation of the phases, the following concentrations of the chemical were
measured.
1-octanol phase
Water phase 0.139 µg/ml
Calculate the log Kow for the chemical.
274 µg/ml
Transcribed Image Text:Draw the structures of the compounds mentioned in the questions below. Circle the functional group that can be ionized You must show your calculations. Benzoic acid has a pKa of 4.20. If it is present in urine that has a pH of 5.68, what is the ratio of the concentrations of the ionized to un-ionized chemical? Calculate the fraction of the total amount of benzoic acid that is ionized in the urine. Aniline has a pKa of 4.6. If it is present in urine that has a pH of 5.45, what is the percentage of aniline that is ionized in the urine? A chemical is subjected to a partition coefficient measurement using 1-octanol and water. After equilibration and separation of the phases, the following concentrations of the chemical were measured. 1-octanol phase Water phase 0.139 µg/ml Calculate the log Kow for the chemical. 274 µg/ml
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