Disorder 4 is associated with the.....Group of answer choicesnuclear DNAribosomeendoplasmic reticulumperoxisome Described below are a collection of five human diseases/disorders, each associated in someway with a cellular organelle. Based on these descriptions and your knowledge of the structureand function of cellular organelles, identify the organelle that is associated with each disorder. Disorder 4:The accumulation of misfolded proteins disrupts the functioning of one specific organelle,leading to induction of the unfolded protein response (UPR) that protects cells against the toxicbuildup of such proteins. However, prolonged stress due to the buildup of these toxic proteinsinduces specific cell death pathways. There is accumulating evidence that this contributes tothe development and progression of neurodegenerative diseases. The accumulation andaggregation of misfolded proteins is linked to occurrence of several neurodegenerativedisorders, including Alzheimer's disease, Parkinson's disease, Amyotrophic lateral sclerosis(ALS), Huntington's disease (HD) and prion diseases.

The proteins are the functional product of a particular gene and they are responsible for all the…

Answered: Disorder 4 is associated with the.....…

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Disorder 4 is associated with the..... Group of answer choices nuclear DNA ribosome endoplasmic reticulum peroxisome

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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Question

Disorder 4 is associated with the.....

Group of answer choices

nuclear DNA

ribosome

endoplasmic reticulum

peroxisome

Described below are a collection of five human diseases/disorders, each associated in some
way with a cellular organelle. Based on these descriptions and your knowledge of the structure
and function of cellular organelles, identify the organelle that is associated with each disorder.

Disorder 4:
The accumulation of misfolded proteins disrupts the functioning of one specific organelle,
leading to induction of the unfolded protein response (UPR) that protects cells against the toxic
buildup of such proteins. However, prolonged stress due to the buildup of these toxic proteins
induces specific cell death pathways. There is accumulating evidence that this contributes to
the development and progression of neurodegenerative diseases. The accumulation and
aggregation of misfolded proteins is linked to occurrence of several neurodegenerative
disorders, including Alzheimer's disease, Parkinson's disease, Amyotrophic lateral sclerosis
(ALS), Huntington's disease (HD) and prion diseases.

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