Discuss the reasons why the proteome is larger than the genome ofa given species.

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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Discuss the reasons why the proteome is larger than the genome of
a given species.

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Introduction

The genome of an individual is referred to as the organism's DNA with all the genes. It includes coding as well as no coding DNA including the mitochondrial and chloroplast DNA.

The proteome on the other hand is the set of complete proteins that can be produced by an organism or cell.

Reason

One reason for the proteome to be larger in comparison to the genome can be the processing of pre-mRNA, which takes place in eukaryotes.

Factors like RNA splicing can alter the codon sequence and produce different forms of proteins with different combinations of amino acid sequences.

The second reason can be post-translational modifications like methylation, phosphorylation, etc.

 

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