You have sequenced the genome of the bacteriumSalmonella typhimurium, and you are using BLAST analysis to identify similarities within the S. typhimuriumgenome to known proteins. You find a protein thatis 100 percent identical in the bacterium Escherichiacoli. When you compare nucleotide sequences of theS. typhimurium and E. coli genes, you find that their nucleotide sequences are only 87 percent identical.a. Explain this observation.b. What do these observations tell you about the meritsof nucleotide- versus protein-similarity searches inidentifying related genes?
You have sequenced the genome of the bacteriumSalmonella typhimurium, and you are using BLAST analysis to identify similarities within the S. typhimuriumgenome to known proteins. You find a protein thatis 100 percent identical in the bacterium Escherichiacoli. When you compare nucleotide sequences of theS. typhimurium and E. coli genes, you find that their nucleotide sequences are only 87 percent identical.a. Explain this observation.b. What do these observations tell you about the meritsof nucleotide- versus protein-similarity searches inidentifying related genes?
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Question
You have sequenced the genome of the bacterium
Salmonella typhimurium, and you are using BLAST analysis to identify similarities within the S. typhimurium
genome to known proteins. You find a protein that
is 100 percent identical in the bacterium Escherichia
coli. When you compare
S. typhimurium and E. coli genes, you find that their nucleotide sequences are only 87 percent identical.
a. Explain this observation.
b. What do these observations tell you about the merits
of nucleotide- versus protein-similarity searches in
identifying related genes?
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