Diclofenac acid has low aqueous solubility (and thus is formulated as diclotenaC sodium. It is desired to prepare a solution of 10 mM diclofenac sodium in water. Can this be done at pH 7.0? At what pH is the maximum solubility observed? Data: pka =5.47 Diclofenac acid solubility, Sa = 0.241 mM Diclofenac sodium solubility, Sa' = 65 mM %3D %3D

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Diclofenac acid has low aqueous solubility (and thus is formulated as diclofenac
sodium. It is desired to prepare a solution of 10 mM diclofenac sodium in water. Can
this be done at pH 7.0? At what pH is the maximum solubility observed?
Data: pKa =5.47
Diclofenac acid solubility, Sa = 0.241 mM
Diclofenac sodium solubility, Sa' = 65 mM
Transcribed Image Text:Diclofenac acid has low aqueous solubility (and thus is formulated as diclofenac sodium. It is desired to prepare a solution of 10 mM diclofenac sodium in water. Can this be done at pH 7.0? At what pH is the maximum solubility observed? Data: pKa =5.47 Diclofenac acid solubility, Sa = 0.241 mM Diclofenac sodium solubility, Sa' = 65 mM
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