Devise the most efficient synthesis for the carboxylic acid below using a starting material and reagents from the tables. Give your route by specifying the number of the starting material followed bythe letters of the reagents you would use beginning with the first step.The answer 4fh means treat t-butanol(4) with conc. HCl(f) then treat the product with KOH in alcohol(h).Starting materialsReagents1Bra Mg/dry etherOH6H₂COHc NaCN/THF or DMF"225"b 1. CO₂ 2. acidic workupd NaCN/dil. aqueous H₂SO4The most efficient synthetic route isBrBr73g PBr3OHOHe Aqueous H₂SO4 at refluxf Conc. HCI or HCI (gas)h KOH/alcoholHot8i KMnO4/H₂O*5Hj Na₂ CrO₂ / aqueous H₂SO4k 1. BH3/THF 2. H₂O₂/aq. NaOHTÅ요

Answered: Image /qna-images/answer/31794f8b-a29d-4578-abb1-d15c6226c46c.jpg

Devise the most efficient synthesis for the carboxylic acid below using a starting material and reagents from the tables. Give your route by specifying the number of the starting material followed by the letters of the reagents you would use beginning with the first step. The answer 4fh means treat t-butanol (4) with conc. HCI(f) then treat the product with KOH in alcohol(h). Starting materials Br H₂C Key OH 7 Reagents Br a Mg/dry ether OH OH b 1. CO₂ 2. acidic workup c NaCN/THF or DMF d NaCN/dil. aqueous H₂SO The most efficient synthetic route is e Aqueous H₂SO, at reflux f Conc. HCI or HCI (gas) 9 PBr h KOH/alcohol HO+ 4 I KMnO₁/H₂O J Na₂ CrO₂ / aqueous H₂SO4 K 1.BHy/THF 2. H₂O₂/aq. NaOH

Devise the most efficient synthesis for the carboxylic acid below using a starting material and reagents from the tables. Give your route by specifying the number of the starting material followed by the letters of the reagents you would use beginning with the first step. The answer 4fh means treat t-butanol (4) with conc. HCI(f) then treat the product with KOH in alcohol(h). Starting materials Br H₂C Key OH 7 Reagents Br a Mg/dry ether OH OH b 1. CO₂ 2. acidic workup c NaCN/THF or DMF d NaCN/dil. aqueous H₂SO The most efficient synthetic route is e Aqueous H₂SO, at reflux f Conc. HCI or HCI (gas) 9 PBr h KOH/alcohol HO+ 4 I KMnO₁/H₂O J Na₂ CrO₂ / aqueous H₂SO4 K 1.BHy/THF 2. H₂O₂/aq. NaOH

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

See similar textbooks

Similar questions

Propose a synthesis for the following product from the starting material(s) indicated. Show all reagents and products of each step of your sequence. Show retrosynthetic analysis. фон OH OH
Propose a strategy for the given synthesis.
1) Different carboxylic acid derivatives react at different rates. Consider reaction below using one or two equivalents of methanol. Predict the major product of the chemical reaction for each the amounts of methanol assuming a base is present. N CH3OH (1 or 2 equiv.)
H₂C OEt H₂C OEt 1. NaOEt, EtOH 2. H₂O* H₂C EtOH OEt Esters, like aldehydes and ketones, are weakly acidic. Treatment of an ester with 1 equivalent of a strong base, such as sodium ethoxide, causes a reversible carbonyl condensation to occur that forms a ẞ-ketoester. This reaction is known as the Claisen condensation. The tetrahedral intermediate thus formed expels an alkoxide leaving group to give an acyl substitution product, a ẞ-ketoester. The steps leading up to this point are all reversible. The best yields for the Claisen condensation are obtained when the starting ester has more than one acidic a-hydrogen. In these cases, a second deprotonation of the a-carbon drives the reaction equilibrium toward the product, thus requiring a full equivalent of base instead of a catalytic amount. Subsequent protonation with dilute aqueous acid resultsn a high yield of the final product. Draw curved arrows to show the movement of electrons in this step of the mechanism. Arrow-pushing…
Give a synthesis for the following molecules. You can use any isomer of butene, C4H8, as a starting material. HOCH, H CƠ H H Br H Br
Fill in the boxes below with the appropriate reagents or structures. Each part includes a hydrolysis reaction, thus the boxes should contain two products (assume that the pH has been adjusted so that the products exist as neutrally charged species).
Devise the most efficient synthesis for the carboxylic acid below using a starting material and reagents from the tables. Give your route by specifying the number of the starting material followed by the letters of the reagents you would use beginning with the first step. The answer 4fh means treat t-butanol (4) with conc. HCl(f) then treat the product with KOH in alcohol(h). CH3 Starting materials Reagents 1 Br OH a Mg / dry ether H3C OH ³4 b 1. CO₂ 2. acidic workup c NaCN/THF or DMF 2 d NaCN/dil. aqueous H₂SO4 The most efficient synthetic route is Br Br 7 3 g HBr f Conc. HCI OH OH e Ethanol, H₂SO4(trace) at reflux h KOH/alcohol Hot 8 i OsO4 5 H j Na₂ CrO4 / aqueous H₂SO4 요 K 1. BH3/THF 2. H₂O₂laq. NaOH
Devise the most efficient synthesis for the carboxylic acid below using a starting material and reagents from the tables. Give your route by specifying the number of the starting material followed by the letters of the reagents you would use beginning with the first step. The answer 4fh means treat t-butanol(4) with conc. HCl(f) then treat the product with KOH in alcohol(h). HO, Starting materials Br Br ton HO. OH H. H3C 1 2 3 он он Br 7 Reagents a Mg / dry ether e Ethanol, H2SO4(trace) at reflux i Os04 b 1. CO2 2. acidic workup f Conc. HCI į Naz Cro4 / aqueous H,SO4 c NACN / THF or DMF 9 HBr k 1. BH3/THF 2. H2O2/aq. NAOH d NaCN / dil. aqueous H2SO4 h КОН/alcohol
Propose a retrosynthetic analysis of benzocaine from the starting material shown. Your answer should include both the synthons and the reagents that would be employed in the actual synthesis. H2N
I don't even know how to begin this synthesis. Does the initial attack by the oxygen of the H on the HCl lead to the formation of the OH group in the carboxylic acid or the OH group on the primary alcohol groups?