starting material followed by the letters of the reagents you would use beginning with the first step. The answer 4fh means treat t-butanol(4) with conc. HCI(f) then treat the product with KOH in alcohol(h). Starting materials Reagents 1 Br a Mg / dry ether H₂C OH D b 1. CO₂ 2. acidic workup c NaCN/THF or DMF 2 d NaCN/dil. aqueous H₂SO4 The most efficient synthetic route is 7 e Ethanol. H₂SO4(trace) at reflux f Conc. HCI g HBr Hot h KOH/alcohol 8 i OsO4 j Na₂ CrO4/ aqueous H₂SO4 k 1. BH₂/THF 2. H₂O₂/aq. NaOH I 요

Chemistry
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Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
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Chapter1: Chemical Foundations
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Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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Devise the most efficient synthesis for the carboxylic acid below using a starting material and reagents from the tables. Give your route by specifying the number of the
starting material followed by the letters of the reagents you would use beginning with the first step.
The answer 4fh means treat t-butanol(4) with conc. HCl(f) then treat the product with KOH in alcohol(h).
Starting materials
Reagents
Br
a Mg/ dry ether
OH
6
OH
H3C
b 1. CO₂ 2. acidic workup
c NaCN/THF or DMF
2
d NaCN/dil. aqueous H₂SO4
The most efficient synthetic route is
Br
Br
7
3
g HBr
f Conc. HCI
e Ethanol, H₂SO4(trace) at reflux
OH
OH
h KOH/alcohol
4
OH
8
i OsO4
5
H
j Na₂ CrO4/ aqueous H₂SO4
I
K 1.BH3/THF 2. H₂O₂/aq. NaOH
요
Transcribed Image Text:Devise the most efficient synthesis for the carboxylic acid below using a starting material and reagents from the tables. Give your route by specifying the number of the starting material followed by the letters of the reagents you would use beginning with the first step. The answer 4fh means treat t-butanol(4) with conc. HCl(f) then treat the product with KOH in alcohol(h). Starting materials Reagents Br a Mg/ dry ether OH 6 OH H3C b 1. CO₂ 2. acidic workup c NaCN/THF or DMF 2 d NaCN/dil. aqueous H₂SO4 The most efficient synthetic route is Br Br 7 3 g HBr f Conc. HCI e Ethanol, H₂SO4(trace) at reflux OH OH h KOH/alcohol 4 OH 8 i OsO4 5 H j Na₂ CrO4/ aqueous H₂SO4 I K 1.BH3/THF 2. H₂O₂/aq. NaOH 요
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