d. What type of inhibition is exhibited against NAD* as a cofactor? Describe what is going on in this type of inhibition. e. Referring to the mechanism below, what step is pyrazole likely interfering with given your answers in c and d? 1. binding of NAD+ to the enzyme, LADH 2. binding of C₂H5OH to LADH 3. Oxidation of C₂H5OH (This is the reaction step) and product dissociation 4. Dissociation of NADH from LADH NAD + LADH NAD LADH + C₂H5OH NAD LADH C₂H5OH NADH LADH NAD LADH k2 NAD LADH C₂H5OH ОН NADH LADH + NADH+ LADH CH3CHO + H
d. What type of inhibition is exhibited against NAD* as a cofactor? Describe what is going on in this type of inhibition. e. Referring to the mechanism below, what step is pyrazole likely interfering with given your answers in c and d? 1. binding of NAD+ to the enzyme, LADH 2. binding of C₂H5OH to LADH 3. Oxidation of C₂H5OH (This is the reaction step) and product dissociation 4. Dissociation of NADH from LADH NAD + LADH NAD LADH + C₂H5OH NAD LADH C₂H5OH NADH LADH NAD LADH k2 NAD LADH C₂H5OH ОН NADH LADH + NADH+ LADH CH3CHO + H
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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