Cells normally repair the lesion O-methylguanine (0°-meG) by directly transferring the methyl group to the protein0-methylguanine-DNA methyltransferase. For the nucleotide sequence AAC(0-meG)TGCAC, with a damaged (methylated) Gresidue, what would be the sequences of both strands of double-stranded DNA resulting from replication in each situation?In the sequences of double-stranded DNA, G" represent 06-meG.Replication occursbefore repairReplication occursafter repairTwo rounds of replicationoccur, followed by repair(5) AACGTGCAC(3) TTGTACGTG(5') AACGTGCAC(3) TTGCACGTG(5) AACG TGCAC(3') TTGT ACGTG(5) AACG TGCAC(3') TTG CACGTGAnswer Bank(5) AACG TGCAC(5) AACGTGCAC(3') TTG CACGTG(3) TTGCACGTG(5) TTG CACGTG(3) AACG TGCAC(5') AACGTGCAC(3') TTGTACGTG(5') AACATGCAC(5) AACG TGCAC(3) TTGTACGTG(3) TIG T ACG G

Solution:This image presents a question about DNA repair, specifically the repair of…

Answered: Cells normally repair the lesion…

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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Similar questions

What is an Okazaki fragment? In which strand of replicating DNA are Okazaki fragments found? Based on the properties of DNA polymerase, why is it necessary to make these fragments?
The restriction endonuclease NciI recognizes and cuts the five-base-pair sequence 5’- CC(G/C)GG-3’ [where (G/C) means either G or C will work at that position]. (1) How often, on average, would this sequence occur in random DNA? Assume the DNA contains 25% each of A, G, T & C. (2) After digestion, Nci1 leaves a one-base 5’ overhang. Write/draw the cut site/digested products.
All guanines in the top strand of the following sequence are converted from the 'keto' tautomer to the 'enol' tautomer, resulting in pairing with thymine. (top strand) 5' TAGCATGCAA 3' (bottom strand) After a few rounds of replication, what will the sequence of the mutated top strand be? (5' to 3') (Newly incorporated nucleotides are in the 'keto' form.) 3' ATCGTACGTT 5'
A DNA fragment with the following base sequence has some cytosine bases that are methylated (indicated by C*) and others that are unmethylated. To determine the locations of methylated and unmethylated cytosines, researchers sequenced this fragment both with and without treatment with sodium bisulfite. Give the sequence of bases that will be read with and without bisulfite treatment. —ATCGC*GTTAC*GTTGC*GTCA—
In Figure 1-8b, can you tell if the number of hydrogenbonds between adenine and thymine is the same as thatbetween cytosine and guanine? Do you think that aDNA molecule with a high content of A + T would bemore stable than one with high content of G + C?
As you should recall, DNA, when not being actively transcribed, has a double helical structure. This portion of the DNA has had the two strands separated in preparation of transcribing for a needed protein. The following is one of the two complimentary strands of DNA: 3' - AACCAGTGGTATGGTGCGATGATCGATTCGAGGCTAAAATACGGATTCGTACGTAGGCACT - 5' Q: Based on written convention, i.e. the 3'-5' orientation, is this the coding strand or the template strand? ______________________________ Q: Assuming this strand extends from base #1 to #61 (going left to right), interpret the correctly transcribed mRNA and translated polypeptide for bases 24 - 47: mRNA: ___-___-___-___-___-___-___-___-___-___-___-___-___-___-___-___-___-___-___-___-___-___-___-___- polypeptide chain: ________--________--________--________--________--________--________--________
a) It is known that double stranded DNA is denatured at low pH. pKa values should allow the determination of whether this is due to perturbation of the hydrogen bonding in A-T and/or G-C base pairs. The table gives values for the pKas of different protonated groups in the nucleobases.Nucleobase Position & pKa A N1, 3.5 G N7, 1.6; N1, 9.2 C N3, 4.2 T N3, 9.7a) Draw the A-T and G-C base pairs. - Label the bases with the one-letter code. – - Number the atoms in the rings and label the atom that attaches to the sugar. - Mark the groups that interact in normal…
Insulin is synthesized as preproinsulin, which has 81 amino acids. How many heterocyclic bases must be present in the informational DNA strand to code for preproinsulin (assuming no introns are present)?
Cytosine can be deaminated to form Uracil What type of mutation is this classified as? Discuss what happens to the base-pairing properties from switching from C to U? When U is replicated in two rounds of synthesis, what substitution does this result in? Before Uracil alters the DNA during replication, what repair system can be used to correct this error? Describe how this type of DNA repair works?
What part(s) of a nucleotide (namely, phosphate, sugar, and/orbase) is(are) found in the major and minor grooves of doublestrandedDNA, and what part(s) is(are) found in the DNA backbone?If a DNA-binding protein does not recognize a specificnucleotide sequence, do you expect that it binds to the majorgroove, the minor groove, or the DNA backbone? Explain.
Even though the eukaryotic genome is thousands of times larger than the prokaryotic genome, DNA replication times are relatively similar. Explain how this is possible.
What would be the anticipated caloric energy needed to construct the human genome from scratch (approximately 3 billion base pairs on 23 individual chromosomes in a diploid state)? Assume that all the purine and pyrimidine bases are pre-existing and abundant ATP and replicating enzymes are not limiting. What would be the estimated daily energy requirement to maintain nuclear supercoiled DNA available for synthetic activities and not quiescent?

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