c) explain the functions of thesc enzymes. 3. Stcroid hormone calcitriol activates an intake of dictary calcium, increasing the amount of Ca" transport protcins in the gut clls. Explain the calcitriol mechanisms of action. For that: a) draw a general scheme of a signal transduction by steroid hormones and explain the process; b) name the molecules, which synthesis is activated by a hormone in the nuclcus of a target el; c) explain the function of these molecules in the cytoplasm of the target ell.
c) explain the functions of thesc enzymes. 3. Stcroid hormone calcitriol activates an intake of dictary calcium, increasing the amount of Ca" transport protcins in the gut clls. Explain the calcitriol mechanisms of action. For that: a) draw a general scheme of a signal transduction by steroid hormones and explain the process; b) name the molecules, which synthesis is activated by a hormone in the nuclcus of a target el; c) explain the function of these molecules in the cytoplasm of the target ell.
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Transcribed Image Text:l zain IQ ?
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Essential Biochemistry
transduction would such changes have? For the answer:
draw the scheme of insulin signal transduction in the target cell;
name proteins and enzymes, activated by insulin in the target eells;
c) explain the functions of these enzymes.
3. Steroid hormone calcitriol activates an intake of dictary calcium, increasing
the amount of Ca" transport proteins in the gut cells. Explain the calcitriol
mechanisms of action. For that:
a) draw a general scheme of a signal transduction by steroid hormones and
explain the process;
b) name the molccules, which synthesis is activated by a hormone in the nucleus
of a target cell;
c) explain the function of these molccules in the cytoplasm of the target cel.
4. Copy Table 4.1 to your notebooks and fill itin.
214
Chapter 4. Structure and functions of biological membranes. Cell signaling pathways
Table 4.1. Adenylyl cyclase and phosphatidylinositol 45-bisphosphate (PIP) signaling pathways
Adenylyl
syclase syatem
Structure and Function
hoshal phosphate
system
An example of the primary messenger
Integral membrane protein, complementary binding the primary
messenger primary
Protein, activating the enzyme of the signaling system
System enzyme, foming the secondary messenger(s)
Secondary messenger(s) of the system
Cytosolic enzyme(s), interacting with the secondary messenger
Regulatory mechanisms (specific to the system) of the metabolic
enzyme activity
Mechanisms of the secondary messenger's concentration
decrease in the targeted cell
The cause of the membrane enzyme activity decrease (specific to
the system)
ситет
5. The sense of smell – is one of the possible ways to detect a signal from the
environment in animals, including humans. It is now acknowledged that human
can detect about 10000 types of smells (odors). Receptors, recciving the seent,
can define molccules differed by only one carbon atom or by one functional
group. The molecule of an odorous substance - odorant, binds to granule-
adsorbent in a mucus composite, covering the olfactory cells in the nasal
cavity. Complex odorant-adsorbent interacts with cell membrane receptor.
The final part of this signal transduction is the opening of CAMP-dependent
Nat-channels in the olfactory cell membrane. This results in excitation
olfactory neuron and transduction of action potential via olfactory nerve to the
central nervous system. Explain the speeificity of all proteins and non-protein
molecules structure, which takes part in the odorant substance transduction.
For that:
a) copy Fig. 4.17 in your notebook and add the required compounds to the
scheme;
b) draw a general structure of the membrane receptor, which interacts with the
complex odorant-adsorbent, if known that such receptors are analogs to the
B,-epinephrine receptors;
e) name the protcin, with one of the protomers is being able to move laterally
through the membrane and transduce the signal to the membrane enzyme;
describe its functions;
d) name the enzyme, which in its active form increases the CAMP concentration
in the olfactory cell; write down the reaction that is catalyzed by this enzyme;
c) make a description of CAMP-dependent Na channels functioning;
the
4.4. Signal Transduction by Intracellular Receptors
215
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