BS21008 Organic Chemistry for the Life Sciences Assignment Week 7 Bearing in mind Huckel's rule, determine whether each of the heterocycles involved in the following acid-base equilibria is aromatic or not (show your working). Use your findings to explain which of the nitrogen atoms in the indazole ring is more basic, i.e. which would be the product of indazole protonation, compound A or compound B? + H* + H* N: N: N-H N. N. H CH3 - H* CH3 - H* CH3 A 1-methyl-1H-indazole B

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BS21008 Organic Chemistry for the Life Sciences
Assignment Week 7
Bearing in mind Huckel's rule, determine whether each of the heterocycles
involved in the following acid-base equilibria is aromatic or not (show your
working). Use your findings to explain which of the nitrogen atoms in the indazole
ring is more basic, i.e. which would be the product of indazole protonation,
compound A or compound B?
+ H*
+ H*
N:
- H*
- H*
H CH3
CH3
CH3
A
1-methyl-1H-indazole
Transcribed Image Text:BS21008 Organic Chemistry for the Life Sciences Assignment Week 7 Bearing in mind Huckel's rule, determine whether each of the heterocycles involved in the following acid-base equilibria is aromatic or not (show your working). Use your findings to explain which of the nitrogen atoms in the indazole ring is more basic, i.e. which would be the product of indazole protonation, compound A or compound B? + H* + H* N: - H* - H* H CH3 CH3 CH3 A 1-methyl-1H-indazole
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