Question 20 Let's say that you are able to colonize the gastrointestinal tract of mice with predominantly firmicutes microflora. There would likely be ... a. weight gain in the mice b. less absorption of short chain fatty acids by the mice O c. increased inflammation in the mice two of the above are correct a, b, and c are all correct Does the Gut Microflora Contribute to Obesity ??? lean obese 1 bacteriodetes 1 firmicutes - promotes breakdown and absorption of fatty acids and polysaccharides weight loss reverses this i.e. more bacteriodetes; less firmicutes colonize with microflora from lean OR obese (ob/ob) mice OUTCOME: - colonization with ob/ob microflora leads to increased body fat in only 2 weeks ! Germ-free mouse - no gut microflora - protected against obesity 10 Turnbaugh et al. Nature Vol 444: 1027, 2006

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Question 20
Let's say that you are able to colonize the gastrointestinal tract of mice with
predominantly firmicutes microflora. There would likely be ...
a. weight gain in the mice
b. less absorption of short chain fatty acids by the mice
O c. increased inflammation in the mice
two of the above are correct
a, b, and c are all correct
Transcribed Image Text:Question 20 Let's say that you are able to colonize the gastrointestinal tract of mice with predominantly firmicutes microflora. There would likely be ... a. weight gain in the mice b. less absorption of short chain fatty acids by the mice O c. increased inflammation in the mice two of the above are correct a, b, and c are all correct
Does the Gut Microflora Contribute to Obesity ???
lean
obese
1 bacteriodetes
1 firmicutes
- promotes breakdown and
absorption of fatty acids and
polysaccharides
weight loss reverses this i.e. more bacteriodetes;
less firmicutes
colonize with microflora from
lean OR obese (ob/ob) mice
OUTCOME:
- colonization with ob/ob
microflora leads to
increased body fat in
only 2 weeks !
Germ-free mouse
- no gut microflora
- protected against obesity
10
Turnbaugh et al. Nature Vol 444: 1027, 2006
Transcribed Image Text:Does the Gut Microflora Contribute to Obesity ??? lean obese 1 bacteriodetes 1 firmicutes - promotes breakdown and absorption of fatty acids and polysaccharides weight loss reverses this i.e. more bacteriodetes; less firmicutes colonize with microflora from lean OR obese (ob/ob) mice OUTCOME: - colonization with ob/ob microflora leads to increased body fat in only 2 weeks ! Germ-free mouse - no gut microflora - protected against obesity 10 Turnbaugh et al. Nature Vol 444: 1027, 2006
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