BIOLOGY ACTIVITY -Gene Mutations and Proteins Objective: To demonstrate how gene mutations affect the production of proteins? Procedure: Use the following base sequence of one strand of an imaginary DNA molecule: AATTGAACACATGCGCCC. 2. Write the base sequence for an mRNA strand that would be transcribed from the given DNA sequence. Place your results in the table below. Use your codon table provided below to determine the sequence of amino acids in the resulting protein fragment. Place your results in the table below. If the fifth base in the original DNA strand were changed from G to C, how would this affect the resulting protein fragment? Write the new protein fragment in the table below. If G were added to the original DNA strand after the third base, what would the resulting mRNA look like? How would this addition affect the protein? Show your results in the table below. Data: mRNA from Step 2 Protein Sequence from Step 3 Protein Sequence from Step 4 mRNA from Step 5 Protein Sequence from Step 5 Conclusions: The two mutations were substitution and a frameshift mutation. Which one was substitution? Which was a frameshift mutation? In what way did the substitution mutation affect the protein? How did the frameshift mutation affect the protein?

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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BIOLOGY ACTIVITY -Gene Mutations and Proteins

Objective: To demonstrate how gene mutations affect the production of proteins?

Procedure:

Use the following base sequence of one strand of an imaginary DNA molecule: AATTGAACACATGCGCCC.
2. Write the base sequence for an mRNA strand that would be transcribed from the given DNA sequence. Place your results in the table below.
Use your codon table provided below to determine the sequence of amino acids in the resulting protein fragment. Place your results in the table below.
If the fifth base in the original DNA strand were changed from G to C, how would this affect the resulting protein fragment? Write the new protein fragment in the table below.
If G were added to the original DNA strand after the third base, what would the resulting mRNA look like? How would this addition affect the protein? Show your results in the table below.

Data:

mRNA from Step 2
Protein Sequence from Step 3
Protein Sequence from Step 4
mRNA from Step 5
Protein Sequence from Step 5

Conclusions:

The two mutations were substitution and a frameshift mutation. Which one was substitution? Which was a frameshift mutation?

In what way did the substitution mutation affect the protein?

How did the frameshift mutation affect the protein?

First Base
A
G
U C
Phenylalanine Serine
Phenylalanine Serine
Leucine
Serine
Leucine
Serine
Proline
Proline
Leucine
Leucine
Leucine
Leucine
Isoleucine
Isoleucine
Secona Base
Isoleucine
Methionine
Valine
Valine
Valine
Valine
Proline
Proline
A G
Tyrosine
Tyrosine
STOP
STOP
Tryptophan
Histidine
Arginine
Histidine Arginine
Cysteine
Cysteine
STOP
Glutamine Arginine
Glutamine
Arginine
Serine
Asparagine Serine
Arginine
Arginine
Aspartic Acid Glycine
Aspartic Acid
Glycine
Threonine Asparagine
Threonine
Threonine
Threonine
Alanine
Alanine
Alanine
Alanine
Lysine
Lysine
Glutamic Acid Glycine
Glutamic Acid
Glycine
U
C
A
G
CAGUUAGUCA
A
U
с
A
G
Third Base
00
+
1
●
Q
+
>

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