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A person (70kg) eating locally caught fish from water contaminated with 100ppb TCE and 100ppb aniline. The bioconcentration value for TCE and aniline in fish is the same at 1.06mg TCE (or aniline) per kg fish, respectively. Fish is only exposed to these contaminants in its environment. About 54g of fish is consumed in 350days/yr for 30years. Assume bioavailability value of 1. The potency factor for TCE is 1.1 × 10$# kg.day/mg and reference dose is 1.00 × 10$% mg/kg.day. Whereas the potency factor for aniline is 5.7 × 10$* kg.day/mg and reference dose (based on drinking water) is 1.60 × 10$& µg/L. Unlike aniline, TCE is not a carcinogenic compound. There are 70yrs in a lifetime and 365day/yr. a) Using chronic daily intake calculation, determine the non-cancer risk (number of people in one million) for the above case. b) Calculate the cancer risk (number of people in million) for the above case.

A person (70kg) eating locally caught fish from water contaminated with 100ppb TCE and 100ppb aniline. The bioconcentration value for TCE and aniline in fish is the same at 1.06mg TCE (or aniline) per kg fish, respectively. Fish is only exposed to these contaminants in its environment. About 54g of fish is consumed in 350days/yr for 30years. Assume bioavailability value of 1. The potency factor for TCE is 1.1 × 10$# kg.day/mg and reference dose is 1.00 × 10$% mg/kg.day. Whereas the potency factor for aniline is 5.7 × 10$* kg.day/mg and reference dose (based on drinking water) is 1.60 × 10$& µg/L. Unlike aniline, TCE is not a carcinogenic compound. There are 70yrs in a lifetime and 365day/yr. a) Using chronic daily intake calculation, determine the non-cancer risk (number of people in one million) for the above case. b) Calculate the cancer risk (number of people in million) for the above case.

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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A person (70kg) eating locally caught fish from water contaminated with 100ppb TCE and 100ppb aniline. The bioconcentration value for TCE and aniline in fish is the same at 1.06mg TCE (or aniline) per kg fish, respectively. Fish is only exposed to these contaminants in its environment. About 54g of fish is consumed in 350days/yr for 30years. Assume bioavailability value of 1. The potency factor for TCE is 1.1 × 10$# kg.day/mg and reference dose is 1.00 × 10$% mg/kg.day. Whereas the potency factor for aniline is 5.7 × 10$* kg.day/mg and reference dose (based on drinking water) is 1.60 × 10$& µg/L. Unlike aniline, TCE is not a carcinogenic compound. There are 70yrs in a lifetime and 365day/yr. a) Using chronic daily intake calculation, determine the non-cancer risk (number of people in one million) for the above case. b) Calculate the cancer risk (number of people in million) for the above case.
Transcribed Image Text:A person (70kg) eating locally caught fish from water contaminated with 100ppb TCE and 100ppb aniline. The bioconcentration value for TCE and aniline in fish is the same at 1.06mg TCE (or aniline) per kg fish, respectively. Fish is only exposed to these contaminants in its environment. About 54g of fish is consumed in 350days/yr for 30years. Assume bioavailability value of 1. The potency factor for TCE is 1.1 × 10$# kg.day/mg and reference dose is 1.00 × 10$% mg/kg.day. Whereas the potency factor for aniline is 5.7 × 10$* kg.day/mg and reference dose (based on drinking water) is 1.60 × 10$& µg/L. Unlike aniline, TCE is not a carcinogenic compound. There are 70yrs in a lifetime and 365day/yr. a) Using chronic daily intake calculation, determine the non-cancer risk (number of people in one million) for the above case. b) Calculate the cancer risk (number of people in million) for the above case.
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