-50 -100 -150 Glutamate + Mg²+ -100 Glutamate, no Mg2+ -50 0 50 Membrane potential (mV) 100 Mg2+ only allows positive ion to enter the cell, causing an inward negative current. The Mg2+ block of the NMDA receptor is removed at this voltage and positive ions leave, causing an outward positive current. Previous O Mg2+ only allows positive ions the to leave the cell, causing an outward positive current. O NMDA receptor with Mg2+ bound is closed at very negative potentials. O The Mg2+ block of the NMDA receptor is removed at this voltage and positive ions enter, causing an inward negative current. Next ▸ Based on the same attached figure as in question 1 above (Figure 6.8A-B in your textbook) describing the NMDA receptor, a ligand-gated ion channel for glutamate, why does the current versus voltage response described by the red line go from near zero to a negative current at around -50 mV? (A) Channel pore Glutamate Mg2+ (B) EPSC (PA) 150 100 50 0 -50 -100 -150 Hyperpolarized, Mg2+ blocks ORA Glutamate + Mg2+ 0/ + Na Ca²+ Glutamate, no Mg2+ Depolarized, no Mg2+ block while K+ 100 Mg2+

-50 -100 -150 Glutamate + Mg²+ -100 Glutamate, no Mg2+ -50 0 50 Membrane potential (mV) 100 Mg2+ only allows positive ion to enter the cell, causing an inward negative current. The Mg2+ block of the NMDA receptor is removed at this voltage and positive ions leave, causing an outward positive current. Previous O Mg2+ only allows positive ions the to leave the cell, causing an outward positive current. O NMDA receptor with Mg2+ bound is closed at very negative potentials. O The Mg2+ block of the NMDA receptor is removed at this voltage and positive ions enter, causing an inward negative current. Next ▸ Based on the same attached figure as in question 1 above (Figure 6.8A-B in your textbook) describing the NMDA receptor, a ligand-gated ion channel for glutamate, why does the current versus voltage response described by the red line go from near zero to a negative current at around -50 mV? (A) Channel pore Glutamate Mg2+ (B) EPSC (PA) 150 100 50 0 -50 -100 -150 Hyperpolarized, Mg2+ blocks ORA Glutamate + Mg2+ 0/ + Na Ca²+ Glutamate, no Mg2+ Depolarized, no Mg2+ block while K+ 100 Mg2+

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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