Assuming that pyrazole is not toxic and that it is transported to the liver, evaluate its potential as an antidote to liver damage in treating chronic alcoholism. Would it be a reasonable therapeutical candidate? Explain.

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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f. There is a proposal that pyrazole could protect against the damaging effects of alcohol on the liver that result
from prolonged decrease in the ratio of [NAD+]/[NADH] caused by the oxidation of alcohol. ( NAD+ is
required for several key dehydrogenation steps in the pathway of glucose synthase. NADH promotes the
accumulation of fat in the liver cells) Assuming that pyrazole is not toxic and that it is transported to the liver,
evaluate its potential as an antidote to liver damage in treating chronic alcoholism. Would it be a reasonable
therapeutical candidate? Explain.

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