-a,ß-unsaturated ketones, aldehydes react with nucleophiles 1,2-addition (direct addition): by R-MgX, LiAlH4 1.4-addition (conjugate addition): by R₂CuLi (Gilman reagent), and most other nucleophiles 1) (CH3)2Culi 2) H+ -MgBr 2)H3O+

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Chapter1: Chemical Foundations
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Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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-a, B-unsaturated ketones, aldehydes react with nucleophiles
1,2-addition (direct addition): by R-MgX, LiAlH4
1.4-addition (conjugate addition): by R₂CuLi (Gilman reagent), and most other nucleophiles
1) (CH3)2CuLi
2) H*
+
1)
-MgBr 2)H₂O+
Transcribed Image Text:-a, B-unsaturated ketones, aldehydes react with nucleophiles 1,2-addition (direct addition): by R-MgX, LiAlH4 1.4-addition (conjugate addition): by R₂CuLi (Gilman reagent), and most other nucleophiles 1) (CH3)2CuLi 2) H* + 1) -MgBr 2)H₂O+
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Step 1: Interpretation of given problem

Given are organic reactions.

Gilman reagent gives 1,4-addition I.e. conjugate addition product.

Grignard reagent gives 1,2-addition product.



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